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激光针刀对兔椎动脉型颈椎病、纤维蛋白原及血液黏度的影响

Laser Needle Knife's Effects on Rabbits Cervical Spondylopathy of Vertebral Artery, Fibrinogen, and Blood Viscosity.

作者信息

Huang Zhenyu, Xie Siwei, Liu Fang, Zhang Ting, Gu Yiwen

机构信息

Department of Acupuncture, Hangzhou Red Cross Hospital, Hangzhou, China.

The Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, China.

出版信息

Front Surg. 2022 Apr 11;9:778608. doi: 10.3389/fsurg.2022.778608. eCollection 2022.

Abstract

OBJECTIVE

To determine the effect of laser needle-knife on vertebroarterial morphology, fibrinogen and blood viscosity in a rabbit model of cervical spondylotic arteriopathy (CSA) and the mechanism of action involved.

METHODS

A number of 40 healthy common grade rabbits were divided into four groups: normal control, model, acupuncture, and laser needle knife group. The normal control group does not establish a CSA rabbit model, and the other groups all establish a CSA rabbit model, but they are treated in different ways. CSA model rabbits were treated with acupuncture and moxibustion at "fengchi" and "cervical Jiaji" points, rabbits in the laser needle knife group were treated with "Jiaji" points, and the acupuncture points were punctured with the laser needle knife. The location of the acupuncture points is determined according to the acupoint map of the experimental map. The right vertebroarterial morphology before and after the treatment was analyzed by scanning electron microscope, and FIB concentration and blood viscosity were determined using the coagulation method.

RESULTS

After the treatment, the capillary and micropore hyperplasia in the laser needle knife group were more evident than that in the model group. Acupuncture and laser needle knife therapy can reduce whole blood viscosity (1/s, 5/s), and that the distinction between the two treatments is not statistically evident.

CONCLUSION

Acupuncture and laser needle knife can regulate the coagulation and fibrinolysis system in CSA, stimulate capillary and micropore hyperplasia, reduce blood viscosity, and improve blood circulation, which may be one of the therapeutic mechanisms behind the laser needle knife treatment of CSA.

摘要

目的

观察针刀对颈椎病性动脉病(CSA)兔椎动脉形态、纤维蛋白原及血液黏度的影响并探讨其作用机制。

方法

将40只健康普通级家兔分为四组:正常对照组、模型组、针刺组和针刀组。正常对照组不建立CSA兔模型,其他组均建立CSA兔模型,但处理方式不同。CSA模型兔针刺“风池”“颈夹脊”穴,针刀组兔针刺“夹脊”穴,用针刀针刺穴位。穴位位置根据实验图谱的穴位图确定。治疗前后用扫描电子显微镜分析右侧椎动脉形态,采用凝固法测定FIB浓度和血液黏度。

结果

治疗后,针刀组毛细血管和微孔增生较模型组更明显。针刺和针刀治疗均可降低全血黏度(1/s、5/s),且两种治疗方法之间的差异无统计学意义。

结论

针刺和针刀可调节CSA中的凝血和纤溶系统,刺激毛细血管和微孔增生,降低血液黏度,改善血液循环,这可能是针刀治疗CSA的作用机制之一。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f97/9035623/3857d1e2452c/fsurg-09-778608-g0001.jpg

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