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来自[植物名称]根茎的二芳基庚烷类类似物及其抗肿瘤活性。 （你提供的原文中“from the rhizomes of”后面缺少具体植物名称）

Diarylheptanoid analogues from the rhizomes of and their anti-tumour activity.

作者信息

Li Ting, Pan Da-Bo, Pang Qian-Qian, Zhou Mi, Yao Xiao-Jun, Yao Xin-Sheng, Li Hai-Bo, Yu Yang

机构信息

Institute of Traditional Chinese Medicine & Natural Products, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University Guangzhou 510632 P. R. China

Department of Medical Technology, Qiandongnan Vocational & Technical College for Nationalities Kaili Guizhou 556000 P. R. China.

出版信息

RSC Adv. 2021 Sep 2;11(47):29376-29384. doi: 10.1039/d1ra03592d. eCollection 2021 Sep 1.

DOI:10.1039/d1ra03592d
PMID:35479564
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9040573/
Abstract

Eight previously undescribed diarylheptanoids (1-8), together with fifteen known analogues (9-23), were isolated from the rhizomes of . Their structures were unambiguously determined by comprehensive spectroscopic analyses and electronic circular dichroism (ECD) calculations. It is worth mentioning that 1-3 are the first reported structures of diaryl ether heptanoids in , whereas 15-17 were isolated from for the first time. Furthermore, a gene enrichment analysis of the interacting targets indicated that diarylheptanoids were mainly associated with the anti-tumor activity by affecting DNA damage signaling pathway. The results showed that 6, 16-19 had remarkable inhibitory effects against five tumor cell lines (A549, HepG2, HeLa, MDA-MB-231, and HCT116) with IC values ranging from 6.69-33.46 μM, and showed down-regulating the expression of ATR (ataxia telangiectasia mutated and RAD3-related) and CHK1 (checkpoint kinase 1) levels in HCT116 and A549 cell lines. Our studies not only enrich the structural diversity of diarylheptanoids in nature, but also discover several natural compounds for anti-tumor agents.

摘要

从……的根茎中分离出8种先前未描述的二芳基庚烷类化合物（1-8）以及15种已知类似物（9-23）。通过全面的光谱分析和电子圆二色性（ECD）计算明确确定了它们的结构。值得一提的是，1-3是首次报道的……中二芳基醚庚烷类化合物的结构，而15-17是首次从……中分离得到。此外，对相互作用靶点的基因富集分析表明，二芳基庚烷类化合物主要通过影响DNA损伤信号通路与抗肿瘤活性相关。结果表明，6、16-19对五种肿瘤细胞系（A549、HepG2、HeLa、MDA-MB-231和HCT116）具有显著抑制作用，IC值范围为6.69-33.46μM，并在HCT116和A549细胞系中下调了ATR（共济失调毛细血管扩张症突变和RAD3相关）和CHK1（检查点激酶1）的表达水平。我们的研究不仅丰富了自然界中二芳基庚烷类化合物的结构多样性，还发现了几种作为抗肿瘤药物的天然化合物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5dbf/9040573/b89ca4129472/d1ra03592d-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5dbf/9040573/6f82eab13280/d1ra03592d-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5dbf/9040573/04bd0598a42e/d1ra03592d-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5dbf/9040573/e8b5c82ccf66/d1ra03592d-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5dbf/9040573/daf7b9bd04ac/d1ra03592d-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5dbf/9040573/b89ca4129472/d1ra03592d-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5dbf/9040573/6f82eab13280/d1ra03592d-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5dbf/9040573/04bd0598a42e/d1ra03592d-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5dbf/9040573/e8b5c82ccf66/d1ra03592d-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5dbf/9040573/daf7b9bd04ac/d1ra03592d-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5dbf/9040573/b89ca4129472/d1ra03592d-f5.jpg

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