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用于卓越抗肿瘤和抗血管生成活性的外泌体包裹核酸支架化疗药物。

Exosome-Encased Nucleic Acid Scaffold Chemotherapeutic Agents for Superior Anti-Tumor and Anti-Angiogenesis Activity.

作者信息

McNamara Ryan P, Eason Anthony B, Zhou Yijun, Bigi Rachele, Griffith Jack D, Costantini Lindsey M, Rudek Michelle A, Anders Nicole M, Damania Blossom A, Dittmer Dirk P

机构信息

Lineberger Comprehensive Cancer Center and Department of Microbiology and Immunology, The University of North Carolina at Chapel Hill School of Medicine, 450 West Drive, Chapel Hill, North Carolina 27599-9500, United States.

Department of Biological and Biomedical Sciences, North Carolina Central University, 1801 Fayetteville Street Durham, North Carolina 27707, United States.

出版信息

ACS Bio Med Chem Au. 2022 Apr 20;2(2):140-149. doi: 10.1021/acsbiomedchemau.1c00030. Epub 2022 Jan 20.

DOI:10.1021/acsbiomedchemau.1c00030
PMID:35480227
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9026271/
Abstract

Extracellular vesicles (EVs), or exosomes, play a pivotal role in tumor growth and metastasis, such as in the case of Kaposi Sarcoma. By loading tumor-derived EVs with chemotherapeutic drugs, we noted that their pro-tumor/pro-angiogenic phenotype was converted into an anti-tumor phenotype . Drug concentration in EVs was significantly higher than in clinically approved liposome formulation, as retention was facilitated by the presence of miRNAs inside the natural EVs. This demonstrates a new mechanism by which to increase the payload capacity of nanoparticles. By exploiting the targeting preferences of tumor-derived EVs, chemotherapeutics can be directed to specifically poison the cells and the microenvironment that enables metastasis.

摘要

细胞外囊泡（EVs），即外泌体，在肿瘤生长和转移中起着关键作用，如在卡波西肉瘤的情况中。通过将化疗药物装载到肿瘤来源的细胞外囊泡中，我们注意到它们的促肿瘤/促血管生成表型转变为抗肿瘤表型。细胞外囊泡中的药物浓度显著高于临床批准的脂质体制剂，因为天然细胞外囊泡内存在的微小RNA有助于药物保留。这证明了一种增加纳米颗粒载药量的新机制。通过利用肿瘤来源细胞外囊泡的靶向偏好，化疗药物可以被定向用于特异性地毒害那些促成转移的细胞和微环境。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07ad/10125181/3862cf95f34c/bg1c00030_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07ad/10125181/1168f4c47a57/bg1c00030_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07ad/10125181/fd0eea44a8ed/bg1c00030_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07ad/10125181/928b7cc462aa/bg1c00030_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07ad/10125181/3862cf95f34c/bg1c00030_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07ad/10125181/1168f4c47a57/bg1c00030_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07ad/10125181/fd0eea44a8ed/bg1c00030_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07ad/10125181/928b7cc462aa/bg1c00030_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07ad/10125181/3862cf95f34c/bg1c00030_0005.jpg

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PEGylated liposomes: immunological responses.
Curr Oncol. 2023 Feb 5;30(2):1924-1944. doi: 10.3390/curroncol30020150.
聚乙二醇化脂质体：免疫反应。
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Exosomes.外泌体。
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Exosome-Mediated Metastasis: Communication from a Distance.外泌体介导的转移：远程通讯。
Dev Cell. 2019 May 6;49(3):347-360. doi: 10.1016/j.devcel.2019.04.011.
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Cellular entry and uncoating of naked and quasi-enveloped human hepatoviruses.裸型和准包膜型人肝炎病毒的细胞进入和脱壳。
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