Salahuddin Nehal, Rehab Ahmed, Emad Sahar
Chemistry Department, Faculty of Science, Tanta University Tanta 31527 Egypt
RSC Adv. 2021 Sep 17;11(48):30183-30194. doi: 10.1039/d1ra04230k. eCollection 2021 Sep 6.
A targeted drug delivery system based on biocompatible magnetic hydrogel nanocomposites consisting of poly[oligo(oxyethylene methacrylate)] anchored FeO nanoparticles was synthesized. The characteristics, thermal properties, morphology and magnetic properties were studied by XRD, FT-IR, TGA, SEM, TEM and VSM. A norfloxacin (NOR) anti-bacterial agent with a potential antitumor activity was immobilized into hydrogels, FeO nanoparticles and their magnetic hydrogel nanocomposites. The drug release manner of NOR was explored at different temperatures and pH values. The behavior of the drug release has been studied different kinetic models. The antibacterial efficacy was tested against , , and well diffusion method, and showed significant activity compared to the unloaded drug. Furthermore, an antitumor efficacy against HCT-116, HepG-2, PC3 and MCF-7 cancer cells revealed the highest cytotoxic efficacy with no influence on healthy cells. These nanodrugs, retaining both antibacterial and anticancer efficacy, have a talented therapeutic potential because of their selective cytotoxicity, connected with the ability to minimize the risk of bacterial infection in a cancer patient who is frequently immunocompromised.
合成了一种基于生物相容性磁性水凝胶纳米复合材料的靶向给药系统，该复合材料由锚定有聚[聚（氧乙烯甲基丙烯酸酯）]的FeO纳米颗粒组成。通过XRD、FT-IR、TGA、SEM、TEM和VSM研究了其特性、热性能、形态和磁性。将具有潜在抗肿瘤活性的诺氟沙星（NOR）抗菌剂固定在水凝胶、FeO纳米颗粒及其磁性水凝胶纳米复合材料中。在不同温度和pH值下探索了NOR的药物释放方式。采用不同的动力学模型研究了药物释放行为。通过平板扩散法对金黄色葡萄球菌、大肠杆菌、枯草芽孢杆菌和白色念珠菌测试了抗菌效果，与未负载药物相比显示出显著活性。此外，对HCT-116、HepG-2、PC3和MCF-7癌细胞的抗肿瘤效果显示出最高的细胞毒性效果，且对健康细胞无影响。这些纳米药物兼具抗菌和抗癌功效，由于其选择性细胞毒性，与降低癌症患者（常免疫功能低下）细菌感染风险的能力相关，具有良好的治疗潜力。
