磁性纳米粒子在乳腺癌定位和治疗中的作用。
The role of magnetic nanoparticles in the localization and treatment of breast cancer.
机构信息
Department of Research Oncology, King's College London, Guy's Hospital Campus, Great Maze Pond, London, UK.
出版信息
Biomed Res Int. 2013;2013:281230. doi: 10.1155/2013/281230. Epub 2013 Jul 9.
Abstract
The role of magnetic nanoparticles (MNPs) in medical applications is rapidly developing. Advances in nanotechnology are bringing us closer to the development of dual and multifunctional nanoparticles that are challenging the traditional distinction between diagnostic and treatment agents. The current use of MNPs in breast cancer falls into four main groups: (1) imaging of primary and metastatic disease, (2) sentinel lymph node biopsy (SLNB), (3) drug delivery systems, and (4) magnetic hyperthermia. The current evidence for the use of MNPs in these fields is mounting, and potential cutting-edge clinical applications, particularly with relevance to the fields of breast oncological surgery, are emerging.
摘要
磁性纳米粒子（MNPs）在医学应用中的作用正在迅速发展。纳米技术的进步使我们更接近于开发双重和多功能纳米粒子，这挑战了诊断和治疗剂之间的传统区别。目前 MNPs 在乳腺癌中的应用主要分为四类：（1）原发性和转移性疾病的成像，（2）前哨淋巴结活检（SLNB），（3）药物输送系统，以及（4）磁热疗。目前，关于这些领域使用 MNPs 的证据越来越多，潜在的前沿临床应用正在出现，特别是与乳腺癌肿瘤外科领域相关。
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