Al Nohair Sultan Fahad, Ahmed Syed Suhail, Ismail Mohamed Saleh, El Maadawy Ahdab Abdo, Albatanony Manal A, Rasheed Zafar
Department of Family and Community Medicine, College of Medicine, Qassim University, Buraidah, Saudi Arabia.
Department of Medical Microbiology, College of Medicine, Qassim University, Buraidah, Qassim, Saudi Arabia.
Open Life Sci. 2022 Apr 6;17(1):351-361. doi: 10.1515/biol-2022-0039. eCollection 2022.
Honey has been used as a traditional remedy for various health benefits. This study investigated the potential of honey against the onset of autoimmune diabetes and its associated secondary complications in type 1 diabetic (T1D) experimental animals. Autoimmune diabetes was induced in Sprague Dawley rats, and at the same time, the rats were treated with honey or metformin. Sandwich ELISAs were used to estimate blood glucose, hemoglobin A1C (HbA1c), total cholesterol, and triglycerides. Histopathological examinations determined the T1D-induced lesions on kidneys, pancreas, cornea, and retina. Treatment of rats with honey during the course of T1D induction showed a significant reduction in fasting-blood-glucose and HbA1c ( < 0.01), and total lipid profile was also improved ( < 0.05). Not only these, but honey also reduced the T1D-induced lesions in the kidney, pancreas, and cornea/retina ( < 0.05). Metformin showed similar effects and was used as a positive control. In conclusion, honey showed therapeutic potential against the onset of autoimmune diabetes, as it reduces blood glucose/HbA1c and improves the lipid profile by reducing the plasma levels of total cholesterol, low-density lipoproteins (LDL), very low-density lipoprotein (VLDL), and triglycerides. Moreover, it also showed protective potential against the development of diabetic nephropathy, pancreatitis, and retinopathy.
蜂蜜一直作为一种具有多种健康益处的传统疗法使用。本研究调查了蜂蜜对1型糖尿病（T1D）实验动物自身免疫性糖尿病发病及其相关继发性并发症的潜在作用。在斯普拉格-道利大鼠中诱导自身免疫性糖尿病，同时用蜂蜜或二甲双胍对大鼠进行治疗。采用夹心酶联免疫吸附测定法来评估血糖、糖化血红蛋白（HbA1c）、总胆固醇和甘油三酯。组织病理学检查确定了T1D诱导的肾脏、胰腺、角膜和视网膜病变。在T1D诱导过程中用蜂蜜治疗大鼠，结果显示空腹血糖和HbA1c显著降低（<0.01），总血脂水平也得到改善（<0.05）。不仅如此，蜂蜜还减少了T1D诱导的肾脏、胰腺和角膜/视网膜病变（<0.05）。二甲双胍显示出类似的效果，并用作阳性对照。总之，蜂蜜显示出对自身免疫性糖尿病发病的治疗潜力，因为它可降低血糖/HbA1c，并通过降低总胆固醇、低密度脂蛋白（LDL）、极低密度脂蛋白（VLDL）和甘油三酯的血浆水平来改善血脂状况。此外，它还显示出对糖尿病肾病、胰腺炎和视网膜病变发展的保护潜力。
