Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, I.R. Iran.
Molecular Medicine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Crit Rev Food Sci Nutr. 2023;63(20):4389-4417. doi: 10.1080/10408398.2021.2001785. Epub 2021 Nov 16.
In spite of achieving substantial progress in its therapeutic strategies, cancer-associated prevalence and mortality are persistently rising globally. However, most malignant cancers either cannot be adequately diagnosed at the primary phase or resist against multiple treatments such as chemotherapy, surgery, radiotherapy as well as targeting therapy. In recent decades, overwhelming evidences have provided more convincing words on the undeniable roles of long non-coding RNAs (lncRNAs) in incidence and development of various cancer types. Recently, phytochemical and nutraceutical compounds have received a great deal of attention due to their inhibitory and stimulatory effects on oncogenic and tumor suppressor lncRNAs respectively that finally may lead to attenuate various processes of cancer cells such as growth, proliferation, metastasis and invasion. Therefore, application of phytochemicals with anticancer characteristics can be considered as an innovative approach for treating cancer and increasing the sensitivity of cancer cells to standard prevailing therapies. The purpose of this review was to investigate the effect of various phytochemicals on regulation of lncRNAs in different human cancer and evaluate their capabilities for cancer treatment and prevention.
尽管在治疗策略方面取得了实质性进展，但癌症相关的患病率和死亡率在全球仍持续上升。然而，大多数恶性癌症要么在早期阶段无法得到充分诊断，要么对化疗、手术、放疗以及靶向治疗等多种治疗方法产生耐药性。近几十年来，大量证据提供了更有说服力的证据，证明长非编码 RNA（lncRNA）在各种癌症类型的发生和发展中起着不可否认的作用。最近，植物化学物质和营养保健品因其对致癌和肿瘤抑制性 lncRNA 分别具有抑制和刺激作用而受到了极大的关注，最终可能会减弱癌细胞的各种过程，如生长、增殖、转移和侵袭。因此，应用具有抗癌特性的植物化学物质可以被认为是治疗癌症和提高癌症细胞对标准现有治疗方法的敏感性的一种创新方法。本综述的目的是研究各种植物化学物质对不同人类癌症中 lncRNA 调节的影响，并评估它们在癌症治疗和预防方面的能力。
