State Key Laboratory of Component-Based Chinese Medicine, Ministry of Education Key Laboratory of Pharmacology of Traditional Chinese Medicine Formulae, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Wolfson Centre for Age-Related Diseases, King's College London, London, UK.
Crit Rev Food Sci Nutr. 2023;63(28):9379-9391. doi: 10.1080/10408398.2022.2067827. Epub 2022 Apr 28.
Aberrant neurogenesis is a major factor in psychiatric and neurological disorders that have significantly attracted the attention of neuroscientists. Curcumin is a primary constituent of curcuminoid that exerts several positive pharmacological effects on aberrant neurogenesis. First, it is important to understand the different processes of neurogenesis, and whether their dysfunction promotes etiology as well as the development of many psychiatric and neurological disorders; then investigate mechanisms by which curcumin affects neurogenesis as an active participant in pathophysiological events. Based on scientometric studies and additional extensive research, we explore the mechanisms by which curcumin regulates adult neurogenesis and in turn affects psychiatric diseases, i.e., depression and neurological disorders among them traumatic brain injury (TBI), stroke, Alzheimer's disease (AD), Gulf War Illness (GWI) and Fragile X syndrome (FXS). This review aims to elucidate the therapeutic effects and mechanisms of curcumin on adult neurogenesis in various psychiatric and neurological disorders. Specifically, we discuss the regulatory role of curcumin in different activities of neural stem cells (NSCs), including proliferation, differentiation, and migration of NSCs. This is geared toward providing novel application prospects of curcumin in treating psychiatric and neurological disorders by regulating adult neurogenesis.
神经发生异常是精神和神经紊乱的主要因素，这引起了神经科学家的高度关注。姜黄素是姜黄素的主要成分，对神经发生异常具有多种积极的药理作用。首先，了解神经发生的不同过程，以及它们的功能障碍是否促进了许多精神和神经紊乱的病因和发展，然后研究姜黄素作为病理生理事件的积极参与者影响神经发生的机制，这一点很重要。基于科学计量学研究和额外的广泛研究，我们探讨了姜黄素调节成年神经发生并进而影响精神疾病（即抑郁症）和神经紊乱（包括创伤性脑损伤（TBI）、中风、阿尔茨海默病（AD）、海湾战争病（GWI）和脆性 X 综合征（FXS））的机制。本综述旨在阐明姜黄素在各种精神和神经紊乱中的成年神经发生的治疗作用和机制。具体来说，我们讨论了姜黄素在神经干细胞（NSC）的不同活动中的调节作用，包括 NSC 的增殖、分化和迁移。这旨在通过调节成年神经发生为治疗精神和神经紊乱提供姜黄素的新应用前景。
