Institut für Organische Chemie, Technische Universität Bergakademie Freiberg, Leipziger Straße 29, 09599, Freiberg, Germany.
ChemMedChem. 2022 Jun 3;17(11):e202200157. doi: 10.1002/cmdc.202200157. Epub 2022 May 24.
The development of new therapeutic approaches for SARS-CoV-2 infections is of particular current importance. The combination therapy proposed here is based on already proven, safe and inexpensive compounds. The natural compound rutin, one of the six therapy components, has the potential to inhibit both viral and host cell targets. In addition, this therapy involves the use of acetylsalicylic acid, vitamin C and vitamin D , which should be administered together with calcium and magnesium. The importance of each component is briefly described in this article. Due to multiple anti-infective properties of rutin, it provides a basis for combating a SARS-CoV-2 infection as well as various viral and bacterial co-infections. There are strong indications for a good effect of this simple combination therapy, especially in the early stages of infection. It has the potential to be of interest both prophylactically and therapeutically, and offers the possibility of protection against severe disease progression.
开发针对 SARS-CoV-2 感染的新治疗方法具有特别重要的现实意义。这里提出的联合治疗方法基于已被证实的、安全且廉价的化合物。天然化合物芦丁是六种治疗成分之一，具有抑制病毒和宿主细胞靶点的潜力。此外，这种治疗方法还涉及使用乙酰水杨酸、维生素 C 和维生素 D，它们应该与钙和镁一起使用。本文简要描述了每个成分的重要性。由于芦丁具有多种抗感染特性，它为对抗 SARS-CoV-2 感染以及各种病毒和细菌的合并感染提供了基础。这种简单联合治疗方法的效果非常显著，尤其是在感染的早期阶段。它具有预防和治疗两方面的潜力，为防止严重疾病进展提供了可能。
