School of Computer Science and Technology, Henan Polytechnic University, Jiaozuo, Henan, 454000, PR China.
School of Computer Science and Technology, Henan Polytechnic University, Jiaozuo, Henan, 454000, PR China; School of Computing and Mathematical Sciences, University of Leicester, Leicester, LE1 7RH, UK.
Comput Biol Med. 2022 Jul;146:105531. doi: 10.1016/j.compbiomed.2022.105531. Epub 2022 Apr 16.
As of Feb 27, 2022, coronavirus (COVID-19) has caused 434,888,591 infections and 5,958,849 deaths worldwide, dealing a severe blow to the economies and cultures of most countries around the world. As the virus has mutated, its infectious capacity has further increased. Effective diagnosis of suspected cases is an important tool to stop the spread of the pandemic. Therefore, we intended to develop a computer-aided diagnosis system for the diagnosis of suspected cases.
To address the shortcomings of commonly used pre-training methods and exploit the information in unlabeled images, we proposed a new pre-training method based on transfer learning with self-supervised learning (TS). After that, a new convolutional neural network based on attention mechanism and deep residual network (RANet) was proposed to extract features. Based on this, a hybrid ensemble model (TSRNet) was proposed for classifying lung CT images of suspected patients as COVID-19 and normal.
Compared with the existing five models in terms of accuracy (DarkCOVIDNet: 98.08%; Deep-COVID: 97.58%; NAGNN: 97.86%; COVID-ResNet: 97.78%; Patch-based CNN: 88.90%), TSRNet has the highest accuracy of 99.80%. In addition, the recall, f1-score, and AUC of the model reached 99.59%, 99.78%, and 1, respectively.
TSRNet can effectively diagnose suspected COVID-19 cases with the help of the information in unlabeled and labeled images, thus helping physicians to adopt early treatment plans for confirmed cases.
截至 2022 年 2 月 27 日,冠状病毒(COVID-19)已在全球范围内导致 434888591 例感染和 5958849 例死亡,给世界大多数国家的经济和文化带来了严重打击。随着病毒的变异,其传染性进一步增强。对疑似病例的有效诊断是阻止大流行传播的重要手段。因此,我们旨在开发一种用于疑似病例诊断的计算机辅助诊断系统。
为了解决常用预训练方法的缺点,并利用未标记图像中的信息,我们提出了一种基于迁移学习和自监督学习(TS)的新预训练方法。之后,提出了一种基于注意力机制和深度残差网络(RANet)的新卷积神经网络,用于提取特征。在此基础上,提出了一种混合集成模型(TSRNet),用于对疑似患者的肺部 CT 图像进行 COVID-19 和正常的分类。
与现有五个模型(DarkCOVIDNet:98.08%;Deep-COVID:97.58%;NAGNN:97.86%;COVID-ResNet:97.78%;基于补丁的 CNN:88.90%)相比,TSRNet 的准确率最高,为 99.80%。此外,该模型的召回率、f1 分数和 AUC 分别达到 99.59%、99.78%和 1。
TSRNet 可以利用未标记和标记图像中的信息有效地诊断疑似 COVID-19 病例,从而帮助医生为确诊病例制定早期治疗计划。