Key Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing 100083, China; College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China.
Key Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing 100083, China.
J Control Release. 2022 Jun;346:405-420. doi: 10.1016/j.jconrel.2022.04.039. Epub 2022 May 4.
Cell-specific aptamers are a promising emerging player in the field of disease therapy. This paper reviews the multidimensional research progress made in terms of their classification, modification, and application. Based on the target location of cell-specific aptamers, it is defined and classified cell-specific aptamers into three groups including aptamers for cell surface markers, aptamers for intracellular components, and aptamers for extracellular components. Moreover, the modification methods of aptamers to achieve improved stability and affinity are concluded. In addition, recent advances in the application of cell-specific aptamers are discussed, mainly focusing on the increasing research attraction of cell state improving helpers and cell recruitment mediators in the improvement of cellular microenvironments to achieve successful disease therapy. This review also highlights 11 types of clinical aptamer drugs. Finally, the challenges and future directions of potential clinical applications are presented. In summary, we believe that cell-specific aptamers are promising drugs in disease therapy.
细胞特异性适体是疾病治疗领域中一种有前途的新兴药物。本文综述了其分类、修饰和应用方面的多维研究进展。根据细胞特异性适体的靶位位置，将其定义并分类为细胞表面标志物适体、细胞内成分适体和细胞外成分适体三类。此外，还总结了适体的修饰方法，以提高其稳定性和亲和力。此外，还讨论了细胞特异性适体的最新应用进展，主要集中在细胞状态改善辅助物和细胞募集介质在改善细胞微环境方面的研究吸引力不断增加，以实现成功的疾病治疗。本文还重点介绍了 11 种临床适体药物。最后提出了潜在临床应用的挑战和未来方向。总之，我们相信细胞特异性适体是疾病治疗中有前途的药物。
