黄芩与 SARS-CoV 3C 样蛋白酶复合物的晶体结构
Crystal structure of SARS-CoV 3C-like protease with baicalein.
机构信息
Applied Biology Laboratory, College of Pharmaceutical and Biological Engineering, Shenyang University of Chemical Technology, Shenyang, 110142, China.
Applied Biology Laboratory, College of Pharmaceutical and Biological Engineering, Shenyang University of Chemical Technology, Shenyang, 110142, China; College of Pharmaceutical Sciences, Gannan Medical University, Ganzhou, 341000, China.
出版信息
Biochem Biophys Res Commun. 2022 Jun 30;611:190-194. doi: 10.1016/j.bbrc.2022.04.086. Epub 2022 Apr 22.
The 3C-like protease (M, 3CL) plays a key role in the replication process in coronaviruses (CoVs). The M is an essential enzyme mediates CoVs replication and is a promising target for development of antiviral drugs. Until now, baicalein has been shown the specific activity for SARS-CoV M in vitro experiments. In this study, we resolved the SARS-CoV M with baicalein by X-ray diffraction at 2.25 Å (PDB code 7XAX), which provided a structural basis for the research and development of baicalein as an anti-CoVs drug.
3C 样蛋白酶（M，3CL）在冠状病毒（CoVs）的复制过程中发挥关键作用。M 是一种重要的酶，介导 CoVs 的复制，是开发抗病毒药物的有前途的靶点。到目前为止，黄芩素已在 SARS-CoV M 的体外实验中显示出特异性活性。在这项研究中，我们通过 X 射线衍射在 2.25 Å（PDB 代码 7XAX）分辨率下解析了 SARS-CoV M 与黄芩素的复合物，为黄芩素作为抗 CoVs 药物的研究和开发提供了结构基础。
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