Chen Hong, Wu Fangsheng, Xu Yibing, Liu Yuan, Song Lun, Chen Xiujuan, He Qun, Liu Wei, Han Qiaoying, Zhang Zihua, Zou Yun, Liu Wenbin
Shanghai Key Laboratory of Crime Scene Evidence, Shanghai Research Institute of Criminal Science and Technology 803 Zhongshan North 1st Road Shanghai 200083 P. R. China
Shanghai Yuansi Standard Science and Technology Co., Ltd. 196 Ouyang Road Shanghai 200080 P. R. China.
RSC Adv. 2021 Sep 6;11(47):29752-29761. doi: 10.1039/d1ra01330k. eCollection 2021 Sep 1.
As a kind of new psychoactive substance (NPS), synthetic cathinones have drawn great worldwide attention. In this study, molecularly imprinted polymers (MIPs), as adsorbents for the extraction and determination of 4-methyldimethcathinone (4-MDMC), were first synthesized by coprecipitation polymerization. The physicochemical analyses of MIPs were successfully performed by XRD, FTIR, FESEM and TGA techniques. Furthermore, rebinding properties of temperature and pH dependence, and selectivity and reusability tests for MIPs and non-imprinted polymers (NIPs) were performed using an ultraviolet-visible spectrometer (UV-vis). The obtained results indicate that the imprinting efficiency has strong dependence on temperature and pH, and the optimal adsorption for targets is achieved under the condition of 318 K and pH = 6.0. This means that the combination between the polymers and 4-MDMC is a strong spontaneous and endothermic process. Compared with NIPs, MIPs exhibit prominent adsorption capacity ( = 9.77 mg g, 318 K). The selectivity coefficients () of MIPs for 4-MDMC, methylenedioxypentedrone (βk-MBDP), 4-ethylmethcathinone (4-EMC), methoxetamine (MXE) and tetrahydrofuranylfentanyl (THF-F) were found to be 1.70, 3.49, 7.14 and 5.82, respectively. Moreover, it was found that the adsorption equilibrium was achieved within 30 min. The aim of this work is the simple synthesis of MIPs and the optimal performance of the molecular recognition of 4-MDMC. Moreover, the synthesized MIPs can be easily regenerated and repeatedly used with negligible loss of efficiency (only 9.94% loss after six times adsorption-desorption tests). Satisfying recoveries in the range of 69.3-78.9% indicate that MIPs have good applicability for analyte removal from urine samples. Ultimately, this material shows great promise for the rapid extraction and separation of synthetic cathinones, which are dissolved in the liquid for the field of criminal sciences.
作为一种新型精神活性物质（NPS），合成卡西酮已引起全球广泛关注。在本研究中，首次通过共沉淀聚合法合成了分子印迹聚合物（MIPs），作为萃取和测定4-甲基二甲基卡西酮（4-MDMC）的吸附剂。利用X射线衍射（XRD）、傅里叶变换红外光谱（FTIR）、场发射扫描电子显微镜（FESEM）和热重分析（TGA）技术成功地对MIPs进行了物理化学分析。此外，使用紫外可见光谱仪（UV-vis）对MIPs的温度和pH依赖性再结合特性以及MIPs和非印迹聚合物（NIPs）的选择性和可重复使用性进行了测试。所得结果表明，印迹效率强烈依赖于温度和pH，在318 K和pH = 6.0的条件下对目标物实现了最佳吸附。这意味着聚合物与4-MDMC之间的结合是一个强烈的自发吸热过程。与NIPs相比，MIPs表现出突出的吸附容量（318 K时， = 9.77 mg g）。发现MIPs对4-MDMC、亚甲基二氧戊酮（βk-MBDP）、4-乙基甲基卡西酮（4-EMC）、甲氧基乙胺（MXE）和四氢呋喃基芬太尼（THF-F）的选择性系数（）分别为1.70、3.49、7.14和5.82。此外，发现吸附平衡在30分钟内达到。这项工作的目的是简单合成MIPs并实现对4-MDMC的分子识别的最佳性能。此外，合成的MIPs可以很容易地再生并重复使用，效率损失可忽略不计（六次吸附-解吸试验后仅损失9.94%）。69.3 - 百分之78.9范围内令人满意的回收率表明MIPs在从尿液样本中去除分析物方面具有良好的适用性。最终，这种材料在快速萃取和分离溶解在液体中的合成卡西酮方面显示出巨大的潜力，适用于刑事科学领域。
