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使用手性氨基亚磷酸酯钌配合物的对映选择性和区域选择性不对称烯丙基取代：实验与理论研究

Enantio- and regioselective asymmetric allylic substitution using a chiral aminophosphinite ruthenium complex: an experimental and theoretical investigation.

作者信息

Jena Rajesh K, Das Dhiraj

机构信息

Centre of Excellence in Advanced Materials and Applications, Utkal University, Vani Vihar Bhubaneswar-751004 India

Department of Chemistry, Indian Institute of Technology Kharagpur Kharagpur 721302 India.

出版信息

RSC Adv. 2021 Dec 9;11(62):39319-39327. doi: 10.1039/d1ra06824e. eCollection 2021 Dec 6.

DOI:10.1039/d1ra06824e
PMID:35492500
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9044493/
Abstract

The design and synthesis of a new chiral aminophosphinite-ligated ruthenium complex is described. The ruthenium complex, [Ru(AMP)(CHCN)][BPh] {AMP = ()--butyl 1-(diphenylphosphinooxy)-3-methylbutan-2-ylcarbamate}, has been found to catalyze nucleophilic addition of phenol and carboxylic acid to allyl chloride in a highly regioselective fashion with enantiomeric excess ranging from 12 to 90.

摘要

描述了一种新型手性氨基亚膦酸酯配位钌配合物的设计与合成。已发现钌配合物[Ru(AMP)(CHCN)][BPh] {AMP = ()-叔丁基 1-(二苯基膦酰氧基)-3-甲基丁-2-基氨基甲酸酯} 能以高度区域选择性的方式催化苯酚和羧酸与烯丙基氯的亲核加成反应，对映体过量值范围为12%至90%。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e79/9044493/17b27499c9b5/d1ra06824e-s4.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e79/9044493/17b27499c9b5/d1ra06824e-s4.jpg

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本文引用的文献

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