通过后转化反应构建功能化二酮哌嗪化合物的非对映选择性合成
Diastereoselective Synthesis of Functionalized Diketopiperazines through Post-transformational Reactions.
机构信息
Peptide Chemistry Research Center, K. N. Toosi University of Technology , P.O. Box 15875-4416, Tehran, Iran.
Medical Biology Research Center, Kermanshah University of Medical Sciences , Kermanshah, Iran.
出版信息
J Org Chem. 2017 Dec 1;82(23):12141-12152. doi: 10.1021/acs.joc.7b01855. Epub 2017 Nov 7.
A diversity-oriented access to diastereoselective arylidene 2,5-diketopiperazines is elaborated via a sequential Ugi post-transformation involving catalytic cyclization and oxidative Heck reaction sequence. This sequence offers an interesting multicomponent entry to a library of 2,5-diketopiperazines and arylidene 2,5-diketopiperazines under mild reaction conditions in good to excellent yields.
通过涉及催化环化和氧化 Heck 反应序列的顺序 Ugi 后转化，精心设计了一种对映选择性芳基烯 2,5-二酮哌嗪的多样性导向方法。该序列在温和的反应条件下，以良好至优异的收率提供了一种有趣的多组分方法，用于合成 2,5-二酮哌嗪和芳基烯 2,5-二酮哌嗪库。
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