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Alarin regulates RyR2 and SERCA2 to improve cardiac function in heart failure with preserved ejection fraction.阿拉林通过调节 RyR2 和 SERCA2 来改善射血分数保留的心力衰竭患者的心功能。
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本文引用的文献

1
Acute central effects of alarin on the regulation on energy homeostasis.阿拉林对能量平衡调节的急性中枢作用。
Neuropeptides. 2017 Aug;64:117-122. doi: 10.1016/j.npep.2016.09.001. Epub 2016 Sep 5.
2
Alarin 6-25Cys antagonizes alarin-specific effects on food intake and luteinizing hormone secretion.阿拉林 6-25Cys 拮抗阿拉林对摄食和促黄体激素分泌的特异性作用。
Neuropeptides. 2013 Feb;47(1):37-41. doi: 10.1016/j.npep.2012.08.007. Epub 2012 Sep 23.
3
Intracerebroventricular administration of galanin antagonist sustains insulin resistance in adipocytes of type 2 diabetic trained rats.脑室注射甘丙肽拮抗剂可维持 2 型糖尿病训练大鼠脂肪细胞的胰岛素抵抗。
Mol Cell Endocrinol. 2012 Sep 25;361(1-2):213-8. doi: 10.1016/j.mce.2012.04.012. Epub 2012 May 4.
4
Effects of alarin on food intake, body weight and luteinizing hormone secretion in male mice.阿拉林对雄性小鼠摄食量、体重和黄体生成素分泌的影响。
Neuropeptides. 2012 Apr;46(2):99-104. doi: 10.1016/j.npep.2011.12.003. Epub 2012 Jan 14.
5
Exercise-induced galanin release facilitated GLUT4 translocation in adipocytes of type 2 diabetic rats.运动诱导的甘丙肽释放促进 2 型糖尿病大鼠脂肪细胞中 GLUT4 的易位。
Pharmacol Biochem Behav. 2012 Jan;100(3):554-9. doi: 10.1016/j.pbb.2011.10.026. Epub 2011 Nov 6.
6
The worldwide epidemiology of type 2 diabetes mellitus--present and future perspectives.2 型糖尿病的全球流行病学——现状与未来展望。
Nat Rev Endocrinol. 2011 Nov 8;8(4):228-36. doi: 10.1038/nrendo.2011.183.
7
Complexity of drug therapy and its implications for quality of diabetes care.药物治疗的复杂性及其对糖尿病护理质量的影响。
World J Diabetes. 2011 Jul 15;2(7):105-7. doi: 10.4239/wjd.v2.i7.105.
8
Galanin antagonist increases insulin resistance by reducing glucose transporter 4 effect in adipocytes of rats.甘丙肽拮抗剂通过减少脂肪细胞中葡萄糖转运蛋白 4 的作用来增加胰岛素抵抗。
Gen Comp Endocrinol. 2011 Aug 1;173(1):159-63. doi: 10.1016/j.ygcen.2011.05.011. Epub 2011 May 31.
9
Galanin-like peptide (GALP) is a hypothalamic regulator of energy homeostasis and reproduction.甘丙肽样肽 (GALP) 是一种下丘脑调节能量平衡和生殖的激素。
Front Neuroendocrinol. 2011 Jan;32(1):1-9. doi: 10.1016/j.yfrne.2010.06.001. Epub 2010 Jun 15.
10
Alarin stimulates food intake in male rats and LH secretion in castrated male rats.阿拉林可刺激雄性大鼠摄食和去势雄性大鼠 LH 分泌。
Neuropeptides. 2010 Aug;44(4):333-40. doi: 10.1016/j.npep.2010.04.001.

2型糖尿病患者血清阿拉林水平的评估

ASSESSMENT OF SERUM ALARIN LEVELS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS.

作者信息

Kilinc F, Demircan F, Gozel N, Onalan E, Karatas A, Pekkolay Z, Özdemir F A

机构信息

Firat University, School of Medicine, Dept. of Endocrinology, Turkey.

Private Etik Life Medical Center Dept. of Internal Diseases, Istanbul, Turkey.

出版信息

Acta Endocrinol (Buchar). 2020 Apr-Jun;16(2):165-169. doi: 10.4183/aeb.2020.165.

DOI:10.4183/aeb.2020.165
PMID:33029232
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7535900/
Abstract

OBJECTIVE

We aimed to investigate the potential relationship between plasma alarin levels and type 2 diabetes mellitus (T2DM).

PATIENTS AND METHOD

We included 154 participants, divided into four groups in a cross-sectional study design. The first group includes patients with T2DM without complications (n=30), the second group patients with T2DM with microvascular complications (T2DM-noC n=32), the third group patients with T2DM with macrovascular complications, T2DM-MV (n=32) and the last group is the healthy control group (n=60).

RESULTS

In our study 94 patients were diabetic; 47 females and 47 males. The control group consists of 60 people, 30 women and 30 men. It was found that these had a significant (p>0.05) variation in serum alarin levels among the T2DM (T2DM-noC=3.1±0.7 ng/mL T2DM-mV=2.8±0.4 ng/mL, T2DM-MV= 3.6±0.4 ng/mL) versus control group (15.6±2.6).We failed to find a significant variation of serum alarin levels (p>0.05) between T2DM subgroups. Serum alarin levels were significantly higher among control patients (p<0.05). There was no difference between diabetic sub-groups.

CONCLUSION

We concluded that serum alarin levels in patients with T2DM are lower than in normal people. Further studies are needed to investigate the possible prognostic value of alarin in clinical practice in T2DM.

摘要

目的

我们旨在研究血浆阿拉辛水平与2型糖尿病（T2DM）之间的潜在关系。

患者与方法

我们纳入了154名参与者，采用横断面研究设计将其分为四组。第一组包括无并发症的T2DM患者（n = 30），第二组为有微血管并发症的T2DM患者（T2DM-noC，n = 32），第三组是有大血管并发症的T2DM患者，即T2DM-MV（n = 32），最后一组是健康对照组（n = 60）。

结果

在我们的研究中，94名患者患有糖尿病；47名女性和47名男性。对照组由60人组成，30名女性和30名男性。结果发现，T2DM组（T2DM-noC = 3.1±0.7 ng/mL，T2DM-mV = 2.8±0.4 ng/mL，T2DM-MV = 3.6±0.4 ng/mL）与对照组（15.6±2.6）之间的血清阿拉辛水平存在显著差异（p>0.05）。我们未发现T2DM亚组之间血清阿拉辛水平有显著差异（p>0.05）。对照组患者的血清阿拉辛水平显著更高（p<0.05）。糖尿病亚组之间没有差异。

结论

我们得出结论，T2DM患者的血清阿拉辛水平低于正常人。需要进一步研究以探讨阿拉辛在T2DM临床实践中的可能预后价值。