结核保护性免疫相关因素研究中的缺失环节：识别受染细胞。
The Missing Link in Correlates of Protective Tuberculosis Immunity: Recognizing the Infected Cell.
机构信息
Department of Medicine, Oregon Health and Science University, Portland, OR, United States.
Pulmonary and Critical Care Medicine, Portland VA Medical Center, Portland, OR, United States.
出版信息
Front Immunol. 2022 Apr 12;13:869057. doi: 10.3389/fimmu.2022.869057. eCollection 2022.
Abstract
For most vaccination studies, the assessment of vaccine-induced CD4 and CD8 T cells has relied upon the measurement of antigen-specific polyfunctional cells, typically using recombinant antigen or peptide pools. However, this approach leaves open the question as to whether or not these cells are responsive to the Mtb-infected cell within the context of Mtb infection and hence leaves open the possibility that a key parameter of vaccine immunogenicity may be overlooked. In this review, we discuss the case that these measurements almost certainly over-estimate the capacity of both CD4 and CD8 T cells to recognize the Mtb-infected cell.
摘要
对于大多数疫苗研究，评估疫苗诱导的 CD4 和 CD8 T 细胞依赖于抗原特异性多功能细胞的测量，通常使用重组抗原或肽库。然而，这种方法留下了一个问题，即这些细胞是否对感染结核分枝杆菌的细胞有反应，因此有可能忽略了疫苗免疫原性的一个关键参数。在这篇综述中，我们讨论了这些测量方法几乎肯定高估了 CD4 和 CD8 T 细胞识别结核分枝杆菌感染细胞的能力。
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2
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