Liu Xiuju, Cheng Qiuli, Zhu Yanlin, Yu Shiyang, Hou Yanyan, Cui Zhanchen, Zhu Song
Department of Prosthetic Dentistry, School and Hospital of Stomatology, Jilin University Changchun 130021 P. R. China
State Key Lab of Supramolecular Structure and Materials, College of Chemistry, Jilin University Changchun 130021 P. R. China.
RSC Adv. 2021 Oct 29;11(55):34699-34709. doi: 10.1039/d1ra06496g. eCollection 2021 Oct 25.
Secondary caries is one of the main causes of dental zirconia restoration failure in the clinic. Therefore, it is urgent to improve the antibacterial performance of zirconia ceramics to reduce the occurrence of secondary caries. In this study, a quaternary ammonium compound antibacterial polymer was innovatively synthesized by solution polymerization with a quaternary ammonium salt monomer as the antibacterial component. The antibacterial epitaxial transition layer was successfully prepared on the surface of zirconia ceramics by the hydroxyl group on HEMA reacting with the siloxane group in the KH570 hydrolysate, which makes the antibacterial polymer indirectly chemically combine with the silicate epitaxial transition layer. The antibacterial epitaxial transition layer exhibited excellent mechanical properties, satisfactory biocompatibility and significant antibacterial effects, and the maximum antibacterial rate is 99%. The antibacterial epitaxial transition layer plays an important role in preventing secondary caries and improving the success rate of clinical zirconia ceramic restorations.
继发龋是临床上牙科氧化锆修复失败的主要原因之一。因此，迫切需要提高氧化锆陶瓷的抗菌性能以减少继发龋的发生。在本研究中，以季铵盐单体为抗菌组分，通过溶液聚合创新性地合成了一种季铵化合物抗菌聚合物。通过甲基丙烯酸羟乙酯（HEMA）上的羟基与硅烷偶联剂KH570水解产物中的硅氧烷基团反应，在氧化锆陶瓷表面成功制备了抗菌外延过渡层，使抗菌聚合物与硅酸盐外延过渡层间接化学结合。该抗菌外延过渡层具有优异的力学性能、良好的生物相容性和显著的抗菌效果，最大抗菌率为99%。抗菌外延过渡层在预防继发龋和提高临床氧化锆陶瓷修复成功率方面发挥着重要作用。
