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对首批核心基因组多位点序列类型CT2050和CT2051菌株及其近亲进行比较基因组分析。

Comparative genome analysis of the first core genome multi-locus sequence types CT2050 AND CT2051 strains with their close relatives.

作者信息

Nwaiwu Ogueri

机构信息

School of Biosciences, University of Nottingham, Sutton Bonington Campus, LE12 5RD.

出版信息

AIMS Microbiol. 2022 Mar 21;8(1):61-72. doi: 10.3934/microbiol.2022006. eCollection 2022.

DOI:10.3934/microbiol.2022006
PMID:35496987
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8995181/
Abstract

Genome sequences of the three strains of , which are the first core genome multi-locus sequence types (cgMLST) 2050 and 2051 were reviewed and compared with 21 close relatives and reference genomes. Using a pan-genomic approach to analyse whole genome sequences, it was found that the strains consisted of approximately 2200 shared genes and a much greater pool of genes present as an accessory genome. An unknown transmissible sequence of approximately 91 kb harbouring bacitracin resistance genes found in strain LmNG2 (1/2b) was revealed to be an Inc18 plasmid. The CT2051, strain LmNG3 (1/2a) haboured more unique genes (252 vs 230) than the well-known reference strain LmEGD-e (1/2a). More studies to monitor new strains can help reduce food-borne outbreaks.

摘要

对三种菌株的基因组序列进行了审查，这三种菌株是首批核心基因组多位点序列类型（cgMLST）2050和2051，并与21个近亲及参考基因组进行了比较。使用泛基因组方法分析全基因组序列，发现这些菌株由大约2200个共享基因和作为辅助基因组存在的大得多的基因库组成。在菌株LmNG2（1/2b）中发现的一个携带杆菌肽抗性基因的约91 kb未知可传播序列被揭示为一种Inc18质粒。CT2051，即菌株LmNG3（1/2a），比著名的参考菌株LmEGD-e（1/2a）拥有更多独特基因（252个对230个）。开展更多监测新菌株的研究有助于减少食源性疾病暴发。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9cb/8995181/cd337e54ec3d/microbiol-08-01-006-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9cb/8995181/5222c529d83e/microbiol-08-01-006-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9cb/8995181/48b684d8db3f/microbiol-08-01-006-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9cb/8995181/cd337e54ec3d/microbiol-08-01-006-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9cb/8995181/5222c529d83e/microbiol-08-01-006-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9cb/8995181/48b684d8db3f/microbiol-08-01-006-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9cb/8995181/cd337e54ec3d/microbiol-08-01-006-g003.jpg

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