Zhang Xi-Wu, Li Qiu-Han, Xu Zuo-di, Dou Jin-Jin
Institute of Chinese Medicine, Heilongjiang University of Chinese Medicine Heping Road 24 Harbin 150040 China
RSC Adv. 2020 Jan 17;10(6):3092-3104. doi: 10.1039/c9ra08985c. eCollection 2020 Jan 16.
Metabolomics is the study of the investigation of small molecules derived from cellular and organism metabolism, which reflects the outcomes of the complex network of biochemical reactions in living systems. As the most recent member of the omics family, there has been notable progress in metabolomics in the last decade, mainly driven by the improvement in mass spectrometry (MS). MS-based metabolomic strategies in modern health and medical science studies provide innovative tools for novel diagnostic and prognostic approaches, as well as an augmented role in drug development, nutrition science, toxicology, and forensic science. In the present review, we not only introduce the application of MS-based metabolomics in the above fields, but also discuss the MS analysis technologies commonly used in metabolomics and the application of metabolomics in precision medicine, and further explore the challenges and perspectives of metabolomics in the field of health and medical science, which are expected to make a little contribution to the better development of metabolomics.
代谢组学是对源自细胞和生物体代谢的小分子进行研究，它反映了生命系统中生物化学反应复杂网络的结果。作为组学家族的最新成员，在过去十年中代谢组学取得了显著进展，这主要得益于质谱（MS）技术的改进。基于质谱的代谢组学策略在现代健康和医学研究中为新型诊断和预后方法提供了创新工具，并且在药物开发、营养科学、毒理学和法医学中发挥着越来越重要的作用。在本综述中，我们不仅介绍基于质谱的代谢组学在上述领域的应用，还讨论代谢组学中常用的质谱分析技术以及代谢组学在精准医学中的应用，并进一步探讨代谢组学在健康和医学科学领域面临的挑战和前景，期望能为代谢组学的更好发展做出一点贡献。
