Ciclitira P J, Stewart J, Evan G, Wight D G, Sikora K
J Clin Pathol. 1987 Mar;40(3):307-11. doi: 10.1136/jcp.40.3.307.
A monoclonal antibody, produced by peptide immunisation was used to detect the distribution of p62c/myc by immunohistology in normal and coeliac small intestinal mucosa. The effect of gluten in four treated coeliac patients was investigated by taking serial jejunal biopsy specimens for six hours after a 10 g oral gluten challenge. There was a progressive increase in p62c/myc staining intensity in the villus enterocytes extending to the crypts, which accompanied the classical morphological changes occurring in the mucosa.
通过肽免疫产生的单克隆抗体，用于通过免疫组织化学检测正常和乳糜泻小肠黏膜中p62c/myc的分布。在4名接受治疗的乳糜泻患者中，口服10克麸质激发后，连续6小时采集空肠活检标本，研究麸质的作用。绒毛肠细胞直至隐窝的p62c/myc染色强度逐渐增加，这与黏膜中发生的典型形态学变化相伴。
