钙掺入Tratt的制备、表征及其对大鼠骨密度的影响
Preparation and Characterization of Calcium-Incorporated Tratt and Its Efficacy on Bone Mineral Density in Rats.
作者信息
Yan Yanfang, Luo Zhongsheng, He Leilei, Wei Fuxiao, Gao Ming, Cui Xiaofang, Yang Juan, Sun Yichun, Li Lilang, Yang Lishou, Deng Tingfei, Pan Xiong, Peng Mei, Tan Yunfei, An Zhengbin, Li Liangqun, Yang Xiaosheng
机构信息
State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, China.
The Key Laboratory of Chemistry for Natural Products of Guizhou Province, Chinese Academy of Sciences, Guiyang 550014, China.
出版信息
Evid Based Complement Alternat Med. 2022 Apr 20;2022:5122396. doi: 10.1155/2022/5122396. eCollection 2022.
The deficiency of traditional calcium preparation will gradually be replaced by the new type of calcium preparation. fruit () is popular for its rich nutrients and functional ingredients. The fermentation broth of , involving amino acids, flavonoids, triterpenes, polysaccharides, and other compounds, is favorable for calcium chelation. Thus, this study fabricated calcium-incorporated (FECa) and further illustrated its efficacy on bone mineral density (BMD) in rats. The calcium holding capacity of FECa was identified and confirmed using AAS. Ion complexation of FECa was characterized using H-NMR, UV, SEM and EDS, and FTIR. The calcium contents of femurs were increased by 36%, and the bone trabeculae of femurs were significantly increased. Net calcium balance was enhanced to further improve BMD by oral administration of FECa. The above results indicate that FECa can be a potential and efficient calcium supplementation agent.
传统钙制剂的不足将逐渐被新型钙制剂所取代。水果（）因其丰富的营养成分和功能成分而受到欢迎。[具体物质]的发酵液含有氨基酸、黄酮类化合物、三萜类化合物、多糖等化合物，有利于钙螯合。因此，本研究制备了含钙[具体物质]（FECa），并进一步阐述了其对大鼠骨密度（BMD）的功效。使用原子吸收光谱法（AAS）鉴定并确认了FECa的钙保留能力。使用氢核磁共振（H-NMR）、紫外可见光谱（UV）、扫描电子显微镜（SEM）、能谱分析（EDS）和傅里叶变换红外光谱（FTIR）对FECa的离子络合进行了表征。股骨的钙含量增加了36%，股骨的骨小梁显著增加。通过口服FECa，净钙平衡得到增强，从而进一步提高骨密度。上述结果表明，FECa可以成为一种潜在且高效的补钙剂。
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