Rapport M D, DuPaul G J
Int Clin Psychopharmacol. 1986 Jan;1(1):45-52. doi: 10.1097/00004850-198601000-00006.
The behavioral effects of CNS stimulants on attention deficit disorder (hyperactive) children's attention are inversely related to their pre-drug rate of behavior, i.e. the effects are rate-dependent. The strength and shape of this relationship are affected by dose and the child's unique reaction to the drug, yet appear unrelated to body weight. Dosage should be directly manipulated in pediatric psychopharmacological studies and the practice of using mg/kg dosage schedules may no longer be necessary.
中枢神经系统兴奋剂对注意力缺陷障碍（多动）儿童注意力的行为影响与用药前行为发生率呈负相关，即这些影响与行为发生率有关。这种关系的强度和形式受剂量以及儿童对药物的独特反应影响，但似乎与体重无关。在儿科精神药理学研究中应直接调整剂量，使用毫克/千克剂量方案的做法可能不再必要。
