Kelway B, Simpson K H, Smith R J, Halsall P J
Int Clin Psychopharmacol. 1986 Oct;1(4):296-302. doi: 10.1097/00004850-198610000-00003.
Memory changes are known to be associated with electroconvulsive therapy (ECT). The anticholinergic drugs used prior to the procedure have also been suspected of causing cognitive deficits. The present study was designed to assess memory and concentration in depressed patients receiving 0.6 mg atropine, 0.2 mg glycopyrrolate or placebo before anaesthesia and ECT. Glycopyrrolate is an anticholinergic agent lacking central nervous system effects. Anaesthesia and bilateral ECT resulted in significant short-term memory deficit, but this was seen equally in each of the groups of patients irrespective of which premedication was given. As no regimen was superior, as far as effect on memory is concerned, premedication for ECT should be chosen according to other criteria.
已知记忆变化与电休克疗法（ECT）有关。该治疗程序之前使用的抗胆碱能药物也被怀疑会导致认知缺陷。本研究旨在评估在麻醉和ECT前接受0.6毫克阿托品、0.2毫克格隆溴铵或安慰剂的抑郁症患者的记忆力和注意力。格隆溴铵是一种缺乏中枢神经系统作用的抗胆碱能药物。麻醉和双侧ECT导致了显著的短期记忆缺陷，但无论给予哪种术前用药，各患者组均出现了这种情况。就对记忆的影响而言，由于没有哪种方案更具优势，ECT的术前用药应根据其他标准来选择。
