Department of Biochemistry, School of Medicine, Boston University, Boston, USA, 02218.
Biochemistry (Mosc). 2022 Jan;87(Suppl 1):S71-S4. doi: 10.1134/S0006297922140061.
Y-box binding proteins (YB proteins) are multifunctional DNA/RNA-binding proteins capable of regulating gene expression at multiple levels. At present, the most studied function of these proteins is the regulation of protein synthesis. Special attention in this review has been paid to the role of YB proteins in the control of mRNA translation and stability at the earliest stages of organism formation, from fertilization to gastrulation. Furthermore, the functions of YB proteins in the formation of germ cells, in which they accumulate in large amounts, are summarized. The review then discusses the contribution of YB proteins to the regulation of gene expression during the differentiation of various types of somatic cells. Finally, future directions in the study of YB proteins and their role in ontogenesis are considered.
Y 盒结合蛋白（YB 蛋白）是一种多功能的 DNA/RNA 结合蛋白，能够在多个层次上调节基因表达。目前，这些蛋白质的研究最多的功能是调节蛋白质合成。本综述特别关注 YB 蛋白在从受精到原肠胚形成的生物体形成的最早阶段控制 mRNA 翻译和稳定性的作用。此外，还总结了 YB 蛋白在大量积累的生殖细胞形成中的功能。然后，该综述讨论了 YB 蛋白在各种类型的体细胞分化过程中对基因表达调控的贡献。最后，考虑了 YB 蛋白及其在个体发生中的作用的未来研究方向。
