Blokhin National Research Center of Oncology, Ministry of Health of the Russian Federation, Moscow, 115478, Russia.
Biochemistry (Mosc). 2022 Jan;87(Suppl 1):S94-202. doi: 10.1134/S0006297922140085.
This review discusses the role of the multifunctional DNA/RNA-binding protein YB-1 in inflammation. YB-1 performs multiple functions in the cell depending on its location: it acts as transcriptional factor for many genes in the nucleus, regulates translation and stability of mRNA in the cytoplasm, and becomes a paracrine factor when secreted from the cells. The review presents the data on the YB-1-mediated regulation of inflammation-associated genes, as well as results of studies on the YB-1 role in animal model of various inflammatory diseases, such as glomerulonephritis, tubulointerstitial fibrosis, and bacterial sepsis, and on the YB-1 expression in different human diseases associated with inflammatory processes in kidney, liver, and endometrium. The last section of the review presents several approaches to the regulation of YB-1 with small molecules in the treatment of inflammatory diseases.
本文综述了多功能 DNA/RNA 结合蛋白 YB-1 在炎症中的作用。YB-1 根据其位置在细胞中发挥多种功能：它作为核内许多基因的转录因子，调节细胞质中 mRNA 的翻译和稳定性，并且当从细胞分泌时成为旁分泌因子。本文介绍了 YB-1 介导的炎症相关基因调节的数据，以及在各种炎症性疾病的动物模型中 YB-1 作用的研究结果，如肾小球肾炎、肾小管间质纤维化和细菌性败血症，以及在与肾脏、肝脏和子宫内膜炎症过程相关的不同人类疾病中 YB-1 的表达。本文的最后一部分介绍了几种用小分子调节 YB-1 的方法，用于治疗炎症性疾病。
