Department of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Department of Nutrition, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Clin Nutr. 2022 Jun;41(6):1260-1271. doi: 10.1016/j.clnu.2022.04.014. Epub 2022 Apr 19.
BACKGROUND & AIMS: Pro-inflammatory diet interacting with gut microbiome might trigger for Crohn's disease (CD). We aimed to investigate the relationship between dietary inflammatory potential and microflora/metabolites change and their link with CD.
The dietary inflammatory potential was assessed using a dietary inflammatory index (DII) based on the Food Frequency Questionnaire from 150 new-onset CD patients and 285 healthy controls (HCs). We selected 41 CD patients and 89 HCs who had not received medication for metagenomic and targeted metabolomic sequencing to profile their gut microbial composition as well as fecal and serum metabolites. DII scores were classified into quartiles to investigate associations among different variables.
DII scores of CD patients were significantly higher than HCs (0.56 ± 1.20 vs 0.23 ± 1.02, p = 0.017). With adjustment for confounders, a higher DII score was significantly associated with higher risk of CD (OR: 1.420; 95% CI: 1.049, 1.923, p = 0.023). DII score also was positively correlated with disease activity (p = 0.001). Morganella morganii and Veillonella parvula were increased while Coprococcus eutactus was decreased in the pro-inflammatory diets group, as well as in CD. DII-related bacteria were associated with disease activity and inflammatory markers in CD patients. Among the metabolic change, pro-inflammatory diet induced metabolites change were largely involved in amino acid metabolic pathways that were also observed in CD.
Pro-inflammatory diet might be associated with increased risk and disease activity of CD. Diet with high DII potentially involves in CD by mediating alterations in gut microbiota and metabolites.
促炎饮食与肠道微生物群相互作用可能引发克罗恩病（CD）。本研究旨在探讨饮食炎症潜能与微生物群/代谢物变化的关系及其与 CD 的关系。
采用基于食物频率问卷的饮食炎症指数（DII）评估 150 例新发 CD 患者和 285 例健康对照者（HCs）的饮食炎症潜能。我们选择了 41 例 CD 患者和 89 例未接受药物治疗的 HCs 进行宏基因组和靶向代谢组测序，以分析其肠道微生物组成以及粪便和血清代谢物。将 DII 评分分为四分位数，以研究不同变量之间的关联。
CD 患者的 DII 评分明显高于 HCs（0.56±1.20 与 0.23±1.02，p=0.017）。调整混杂因素后，较高的 DII 评分与 CD 的发病风险显著相关（OR：1.420；95%CI：1.049，1.923，p=0.023）。DII 评分与疾病活动度也呈正相关（p=0.001）。Morganella morganii 和 Veillonella parvula 在促炎饮食组中增加，Coprococcus eutactus 在 CD 中减少。与 DII 相关的细菌与 CD 患者的疾病活动度和炎症标志物相关。在代谢变化中，促炎饮食诱导的代谢物变化主要涉及氨基酸代谢途径，这在 CD 中也观察到。
促炎饮食可能与 CD 的发病风险和疾病活动度增加有关。高 DII 饮食可能通过调节肠道微生物群和代谢物的变化而参与 CD 的发病。
