Department of Perioperative Medicine, Clinical Center, NIH, Bethesda, Maryland.
Department of Perioperative Medicine, Clinical Center, NIH, Bethesda, Maryland.
J Pain. 2022 Oct;23(10):1646-1650. doi: 10.1016/j.jpain.2022.04.009. Epub 2022 Apr 30.
The strong need for a new foundational molecular framework for human nervous system research at the nociceptive level is now matched by comprehensive and quantitative capabilities for analyzing nociceptive tissues such as pathologic peripheral tissue, damaged peripheral nerve, dorsal root ganglia, spinal cord, and brain, where possible. However, this idea must be matched by equally strong organization and infrastructures for multisite tissue recovery, molecular analyses, data sharing, and long-term archiving. Experience from other human tissue analysis projects shows that a decades-long activity may be expected, hence "Be in it for the long haul." While certain milestones can be met fairly quickly, others aimed at molecular and neuroanatomical characterization of chronic pain disorders will require the sustained attention of the groups involved. This can yield a valuable addition to basic and translational pain research and the development of new treatments whose targets are validated directly in humans. PERSPECTIVE: A concerted effort is needed to build human nociceptive tissue banks for multi-omic research. In addition to collecting tissue, a careful characterization of pain problems from donors is essential, as is a parallel effort to assess their concurrent medical problems, medications, and the many variables of general human activity and lifestyle that can impact the results. Given the projected long time frame, in addition to maintaining funding, sustaining motivation and momentum are critical factors for success.
现在强烈需要一个新的基础分子框架来研究人类神经系统在痛觉层面的问题，同时还需要全面和定量的能力来分析痛觉组织，如病变的周围组织、受损的周围神经、背根神经节、脊髓和大脑，如果可能的话。然而，这一想法必须与多地点组织回收、分子分析、数据共享和长期存档的同样强大的组织和基础设施相匹配。来自其他人类组织分析项目的经验表明，可能需要长达数十年的活动，因此需要“长期投入”。虽然某些里程碑可以相当快地实现，但其他旨在对慢性疼痛障碍进行分子和神经解剖学特征描述的目标将需要相关小组的持续关注。这将为基础和转化疼痛研究以及新疗法的开发做出有价值的贡献，这些新疗法的靶点可以直接在人体中得到验证。观点：需要齐心协力建立用于多组学研究的人类痛觉组织库。除了收集组织外，还必须仔细描述供体的疼痛问题，同时平行评估他们同时存在的医疗问题、药物以及许多可能影响结果的一般人类活动和生活方式的变量。考虑到预计的时间框架较长，除了保持资金投入外，保持动力和势头是成功的关键因素。
