Janssen Research and Development, LLC, La Jolla, CA, USA; Department of Urology, University of Michigan, Ann Arbor, MI, USA.
Alliance Statistics and Data Management Center, Mayo Clinic, Rochester, MN, USA.
Eur Urol Focus. 2022 Nov;8(6):1607-1616. doi: 10.1016/j.euf.2022.03.007. Epub 2022 Apr 30.
Health-related quality of life (HRQoL) among patients with localized prostate cancer (PC) on active surveillance (AS) and whether it may be improved through lifestyle-focused interventions remain underdefined.
To assess longitudinal changes in HRQoL in patients who received and those who did not receive a behavioral intervention that increased vegetable intake.
DESIGN, SETTING, AND PARTICIPANTS: A secondary analysis of participants in the Men's Eating and Living (MEAL) study (Cancer and Leukemia Group 70807 [Alliance]), a randomized trial of vegetable consumption in patients on AS, was conducted.
Patient-reported outcomes (PROs) included the Memorial Anxiety Scale for Prostate Cancer (MAX-PC), the Expanded Prostate Cancer Index Composite 26 (EPIC-26), and the Functional Assessment of Cancer Therapy Scale-Prostate (FACT-P). Areas under the curves (AUCs) were used to summarize serial HRQoL.
PROs were completed in 87% (n = 387) of the intention-to-collect population. Baseline characteristics of patients completing HRQoL measures did not differ significantly from the entire study population or between groups. Baseline scores were high for all PROs and remained stable over 24 mo, with no significant differences from baseline at any time point. In adjusted analyses, there were no significant differences in summary AUC measures comparing control with intervention for the total MAX-PC score (p = 0.173); EPIC-26 domains of urinary incontinence (p = 0.210), urinary obstruction (p = 0.062), bowel health (p = 0.607), sexual health (p = 0.398), and vitality (p = 0.363); and total FACT-P scores (p = 0.471).
Among men with localized PC on AS enrolled in a randomized trial, HRQoL was high across multiple domains at baseline, remained high during follow-up, and did not change in response to a behavioral intervention that increased vegetable intake.
Patients with localized prostate cancer enrolled on active surveillance experience minimal cancer-associated anxiety, suffer low levels of cancer-associated symptoms, and perceive high physical and emotional well-being.
局限性前列腺癌（PC）患者接受主动监测（AS）时的健康相关生活质量（HRQoL）以及生活方式为重点的干预措施是否可以改善这一质量，目前仍不明确。
评估接受或未接受增加蔬菜摄入量的行为干预的患者的 HRQoL 的纵向变化。
设计、地点和参与者：对 Men's Eating and Living（MEAL）研究（癌症和白血病组 70807[联盟]）中接受 AS 的患者的蔬菜摄入量随机试验参与者进行了二次分析。
患者报告的结果（PRO）包括前列腺癌焦虑量表（MAX-PC）、前列腺癌指数综合量表 26 版（EPIC-26）和癌症治疗功能评估-前列腺量表（FACT-P）。曲线下面积（AUC）用于总结连续的 HRQoL。
意向收集人群中完成 PRO 的比例为 87%（n=387）。完成 HRQoL 测量的患者的基线特征与整个研究人群或两组之间没有显著差异。所有 PRO 的基线评分均较高，在 24 个月内保持稳定，在任何时间点与基线均无显著差异。在调整分析中，与对照组相比，干预组的总 MAX-PC 评分的汇总 AUC 测量值没有显著差异（p=0.173）；尿失禁（p=0.210）、尿路梗阻（p=0.062）、肠道健康（p=0.607）、性功能（p=0.398）和活力（p=0.363）的 EPIC-26 域；以及总 FACT-P 评分（p=0.471）。
在参加随机试验的接受 AS 的局限性 PC 男性中，多个领域的 HRQoL 在基线时较高，随访期间保持较高水平，并且对增加蔬菜摄入量的行为干预没有变化。
接受主动监测的局限性前列腺癌患者经历的癌症相关焦虑程度较低，癌症相关症状水平较低，身体和情绪健康状况较好。
