Department of Immunology, Tumor Immunology group, Leiden University Medical Center, Leiden, The Netherlands.
Methods Mol Biol. 2022;2451:589-596. doi: 10.1007/978-1-0716-2099-1_30.
Photodynamic therapy (PDT) for cancer not only strongly reduces tumor mass but can also induce or enhance immune responses against the tumor by causing the release of tumor antigen and danger signals from dying tumor cells. This supports combinations of PDT and immunotherapy for the treatment of advanced tumors for which single therapies are insufficiently effective. Immune checkpoint blockade is a prominent type of cancer immunotherapy that aims to restore the effector function of immune cells, most often T cells, by administering antibodies that block inhibitory molecules. In this chapter, we describe the combination of PDT with immune checkpoint blockade in a mouse tumor model.
光动力疗法（PDT）不仅可以强烈减少肿瘤体积，还可以通过诱导或增强肿瘤细胞死亡释放肿瘤抗原和危险信号来诱导或增强针对肿瘤的免疫反应。这支持 PDT 与免疫疗法联合用于治疗单一疗法效果不足的晚期肿瘤。免疫检查点阻断是一种重要的癌症免疫疗法，旨在通过施用阻断抑制性分子的抗体来恢复免疫细胞（最常为 T 细胞）的效应功能。在本章中，我们描述了在小鼠肿瘤模型中 PDT 与免疫检查点阻断的联合应用。
