Levine A S, Sievert C E, Morley J E, Gosnell B A, Silvis S E
Peptides. 1984 Jul-Aug;5(4):675-9. doi: 10.1016/0196-9781(84)90005-6.
Although the incidence of obesity in the domesticated dog is high, few studies have investigated the regulation of food intake in this species. In the present study we investigated the response of the dog to a number of putative satiety agents including cholecystokinin (CCK), bombesin, calcitonin and naloxone. CCK significantly suppressed food intake during a scheduled fifteen minute meal in intact dogs and in dogs receiving total subdiaphragmatic vagotomies. Emesis occurred following injection of higher doses of CCK in most dogs. Bombesin and calcitonin reduced intake in both normal and vagotomized dogs, although higher doses of calcitonin were needed to significantly suppress feeding in vagotomized dogs compared with intact animals. Naloxone reduced feeding by as much as 60% in intact and vagotomized animals. Glucagon suppressed feeding in intact dogs, but not in vagotomized animals. Somatostatin and pancreatic polypeptide did not alter food intake. Thus the domesticated dog responds somewhat differently to some neuropeptides compared with the laboratory rat stressing the importance of examining the regulation of food intake across species.
虽然家养犬肥胖的发生率很高，但很少有研究调查该物种的食物摄入调节。在本研究中，我们研究了犬对多种假定的饱腹感因子的反应，包括胆囊收缩素（CCK）、蛙皮素、降钙素和纳洛酮。CCK在完整犬和接受完全膈下迷走神经切断术的犬的预定15分钟进食期间显著抑制食物摄入。大多数犬注射高剂量CCK后出现呕吐。蛙皮素和降钙素在正常犬和迷走神经切断犬中均减少摄入量，尽管与完整动物相比，需要更高剂量的降钙素才能显著抑制迷走神经切断犬的进食。纳洛酮使完整和迷走神经切断动物的进食减少多达60%。胰高血糖素抑制完整犬的进食，但不抑制迷走神经切断动物的进食。生长抑素和胰多肽不改变食物摄入量。因此，与实验室大鼠相比，家养犬对某些神经肽的反应有所不同，这强调了跨物种研究食物摄入调节的重要性。
