Silver A J, Flood J F, Morley J E
Geriatric Research, Education and Clinical Center (GRECC), Veterans Administration Hospital, Sepulveda, CA 91343.
Peptides. 1988 Mar-Apr;9(2):221-5. doi: 10.1016/0196-9781(88)90254-9.
Early satiety may play a role in the anorexia of aging. The effects of the peripheral satiety agents cholecystokinin (CCK), bombesin, glucagon, and calcitonin were studied in 8 and 25 month old mice. During normal feeding behavior, the older mice consumed more than their younger counterparts, however, when food deprived, the younger consumed more. All peptides inhibited food intake over the first hour after administration in young and old mice. CCK, bombesin, and calcitonin suppressed feeding in 25 month old mice to a greater extent than in 8 month old mice. However, CCK demonstrated the greatest age-related suppression of food intake. CCK has a potential role to play in the pathogenesis of the anorexia of aging.
早饱可能在衰老性厌食中起作用。研究了外周饱腹感因子胆囊收缩素（CCK）、蛙皮素、胰高血糖素和降钙素对8月龄和25月龄小鼠的影响。在正常进食行为期间，老年小鼠的食量超过年轻小鼠，但在禁食时，年轻小鼠的食量更大。在给药后的第一个小时内，所有肽类均抑制了年轻和老年小鼠的食物摄入。CCK、蛙皮素和降钙素对25月龄小鼠进食的抑制作用比8月龄小鼠更大。然而，CCK对食物摄入的抑制作用随年龄增长最为显著。CCK在衰老性厌食的发病机制中可能发挥作用。
