Selçuk University, Division of Sports Physiology, Department of Physiology, Faculty of Medicine, Selçuklu, 42131, Konya, Turkey.
An Acad Bras Cienc. 2022 May 2;94(2):e20200265. doi: 10.1590/0001-3765202220200265. eCollection 2022.
This study examined the effects of low-intensity eccentric exercise training performed before high-intensity eccentric exercise on muscle damage markers, oxidative stress and antioxidant defense. Twenty-two rats were divided into 3 groups; control (CON; n = 6), high-intensity eccentric exercise (HE; n = 8) and low-intensity eccentric exercise training plus high-intensity eccentric exercise (LET + HE; n = 8). Rats in the HE group performed HE at once. Rats in the LET + HE group performed LET and then HE protocol was applied. Blood and vastus intermedius muscle samples were taken 24 hours after the last exercise session for analyses of muscle damage, oxidative stress, and antioxidant defense markers. Muscle damage markers were higher in the HE group than the CON (137%-488%) and the LET + HE groups (82%-110%) (P < 0.05). Oxidative stress marker was higher in the HE group than the CON (65%) and the LET + HE (50%) groups (P < 0.05). Antioxidant defense markers were higher in the LTE + HE group than the HE group (39%-51%) (P < 0.05). In conclusion, low-intensity eccentric exercise training performed before high-intensity eccentric exercise conferred a protective effect against muscle damage by reducing oxidative stress and increasing antioxidant defense.
本研究旨在探讨高强度离心运动前进行低强度离心运动训练对肌肉损伤标志物、氧化应激和抗氧化防御的影响。将 22 只大鼠分为 3 组：对照组（CON；n = 6）、高强度离心运动组（HE；n = 8）和低强度离心运动训练加高强度离心运动组（LET + HE；n = 8）。HE 组大鼠立即进行 HE。LET + HE 组大鼠先进行 LET，然后应用 HE 方案。最后一次运动后 24 小时采集血液和股中间肌样本，用于分析肌肉损伤、氧化应激和抗氧化防御标志物。HE 组的肌肉损伤标志物高于 CON（137%-488%）和 LET + HE（82%-110%）组（P<0.05）。HE 组的氧化应激标志物高于 CON（65%）和 LET + HE（50%）组（P<0.05）。LTE + HE 组的抗氧化防御标志物高于 HE 组（39%-51%）（P<0.05）。综上所述，高强度离心运动前进行低强度离心运动训练通过降低氧化应激和增加抗氧化防御，对肌肉损伤具有保护作用。
