下丘脑内注射胰岛素可降低交感神经的放电频率。
Intrahypothalamic injection of insulin decreases firing rate of sympathetic nerves.
作者信息
Sakaguchi T, Bray G A
出版信息
Proc Natl Acad Sci U S A. 1987 Apr;84(7):2012-4. doi: 10.1073/pnas.84.7.2012.
Abstract
Injection of picomolar quantities of insulin into the ventromedial hypothalamus of rats significantly reduced the firing rate of sympathetic nerves that supply interscapular brown adipose tissue. The minimal firing rate was reached in 2 min, and the effect was gone within 4 min. The effect of insulin was dose-related and did not occur when comparable volumes of physiological saline were injected into the ventromedial hypothalamus. Destruction of neurons in the ventromedial hypothalamus by injection of kainic acid abolished the inhibitory effects of insulin. These data suggest that insulin may play a role in modulating the sympathetic firing rate to thermogenically important tissues.
摘要
向大鼠腹内侧下丘脑注射皮摩尔量的胰岛素，可显著降低支配肩胛间棕色脂肪组织的交感神经的放电频率。在2分钟内达到最低放电频率，且该效应在4分钟内消失。胰岛素的作用呈剂量依赖性，当向腹内侧下丘脑注射等量的生理盐水时则不会出现这种效应。通过注射 kainic 酸破坏腹内侧下丘脑的神经元，可消除胰岛素的抑制作用。这些数据表明，胰岛素可能在调节对产热重要组织的交感神经放电频率中发挥作用。
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