慢性肺部疾病中的生物钟分子节律紊乱。
Circadian molecular clock disruption in chronic pulmonary diseases.
机构信息
Department of Internal Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, University of Kansas Medical Center, Kansas City, KS, USA.
Department of Environmental Medicine, School of Medicine and Dentistry, University of Rochester Medical Center, Rochester, NY, USA.
出版信息
Trends Mol Med. 2022 Jun;28(6):513-527. doi: 10.1016/j.molmed.2022.04.002. Epub 2022 May 1.
Abstract
The circadian clock is the biochemical oscillator with a near 24-h period that is responsible for generating the circadian rhythms in peripheral organs including the lung. Mounting evidence suggests that circadian clock disruption during chronic lung diseases plays an essential role in augmented oxidative stress, inflammatory response, metabolic imbalances, hypoxia/hyperoxia, mucus secretion, dysregulated autophagy, and alters pulmonary function. Here, we review circadian clock disruption and discuss candidate clock genes that are altered at the transcriptional or translational level in chronic pulmonary diseases. This review aims to provide the current knowledge and understanding of the circadian molecular clock disruption in chronic pulmonary diseases which will further advance the development of novel clock-based therapeutics in the future.
摘要
生物钟是一种具有近 24 小时周期的生化振荡器，负责产生肺部等外周器官的昼夜节律。越来越多的证据表明，慢性肺部疾病期间生物钟紊乱在增强氧化应激、炎症反应、代谢失衡、低氧/高氧、黏液分泌、自噬失调和改变肺功能方面起着至关重要的作用。在这里，我们综述了生物钟紊乱，并讨论了在慢性肺部疾病中在转录或翻译水平上发生改变的候选时钟基因。本综述旨在提供对慢性肺部疾病中昼夜分子钟紊乱的现有认识和理解，这将进一步推动未来基于时钟的治疗方法的发展。
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