Gurung Sanyukta, Mahotra Narayan Bahadur, Shrestha Lava, Sherpali Aakash, Joshi Surya Prakash, Shrestha Gambhir, Shrestha Shailesh, Shakya Aman, Kandel Manoj
Department of Clinical Physiology, Maharajgunj Medical Campus, Institute of Medicine, Tribhuvan University, Kathmandu, Nepal.
Maharajgunj Medical Campus, Institute of Medicine, Tribhuvan University, Kathmandu, Nepal.
SAGE Open Med. 2022 Apr 28;10:20503121221095413. doi: 10.1177/20503121221095413. eCollection 2022.
Recent studies after the outbreak of coronavirus disease 2019 have shown an association of the ABO blood group to the susceptibility of severe acute respiratory syndrome coronavirus 2 infection. Anti-A and anti-B antibodies, carbohydrate clustering, interleukin-6 levels and host transmembrane protease serine subtype 2 were suggested to cause the variable susceptibility of severe acute respiratory syndrome coronavirus 2 infection to the ABO blood groups. This study aims to find the association of the ABO blood group with severe acute respiratory syndrome coronavirus 2 infection susceptibility in Nepal.
Population-based matched case-control study was conducted from October 2021 to February 2022 in Rupandehi district of Nepal. A total of 1091 reverse transcription-polymerase chain reaction confirmed coronavirus disease 2019 cases and 2182 controls were included in the study by convenient sampling method.
A statistically significant association of severe acute respiratory syndrome coronavirus 2 infection was observed for the blood group AB between cases and controls (11.5% vs 8.5%; odds ratio = 1.4, 95% confidence interval = 1.10-1.78). However, there was no association of severe acute respiratory syndrome coronavirus 2 infection for blood group A (26.7% vs 28.23%; odds ratio = 0.93, 95% confidence interval = 0.79-1.09), B (26.9% vs 29.84%; odds ratio = 0.86, 95% confidence interval = 0.73-1.02) and O (34.9% vs 33.41%; odds ratio = 1.07, 95% confidence interval = 0.92-1.25).
This study reported slightly more susceptibility to severe acute respiratory syndrome coronavirus 2 infection among individuals with blood group AB.
2019年冠状病毒病爆发后的近期研究表明，ABO血型与严重急性呼吸综合征冠状病毒2感染的易感性有关。抗A和抗B抗体、碳水化合物聚集、白细胞介素-6水平和宿主跨膜蛋白酶丝氨酸亚型2被认为导致严重急性呼吸综合征冠状病毒2感染对ABO血型的易感性存在差异。本研究旨在探讨尼泊尔ABO血型与严重急性呼吸综合征冠状病毒2感染易感性之间的关联。
2021年10月至2022年2月在尼泊尔鲁潘德希区进行了基于人群的配对病例对照研究。通过方便抽样法，共纳入1091例经逆转录聚合酶链反应确诊的2019年冠状病毒病病例和2182例对照。
病例组和对照组中，AB血型个体的严重急性呼吸综合征冠状病毒2感染存在统计学显著关联（11.5%对8.5%；比值比=1.4，95%置信区间=1.10-1.78）。然而，A血型（26.7%对28.23%；比值比=0.93，95%置信区间=0.79-1.09）、B血型（26.9%对29.84%；比值比=0.86，95%置信区间=0.73-1.02）和O血型（34.9%对33.41%；比值比=1.07，95%置信区间=0.92-1.25）的严重急性呼吸综合征冠状病毒2感染无关联。
本研究报告AB血型个体对严重急性呼吸综合征冠状病毒2感染的易感性略高。
