Laboratory of Chemical Bioscience, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University (TMDU), 2-3-10 Kanda-Surugadai, Chiyoda-ku, Tokyo 101-0062, Japan.
Laboratory for Chemical Biology, RIKEN Center for Biosystems Dynamics Research, 6-7-3 Minatojima-minamimachi, Chuo-ku, Kobe 650-0047, Japan.
Chem Commun (Camb). 2022 May 24;58(42):6235-6238. doi: 10.1039/d2cc01739c.
The iridium-catalyzed azide-thioalkyne cycloaddition was found to proceed much faster with benzyl azide than with phenyl azide. The high azido-type selectivity was also observed in other combinations of azides with different steric environments. This finding enabled the efficient assembly of three azidophilic molecules to triazido platforms by three sequential triazole-forming reactions.
铱催化的叠氮化物-硫代炔烃环加成反应发现，苄基叠氮化物的反应速度比苯基叠氮化物快得多。在不同空间位阻环境的叠氮化物与其他组合中也观察到高的叠氮类型选择性。这一发现使三个亲叠氮分子通过三个连续的三唑形成反应有效地组装到三叠氮平台上。
