Department of Infectious Diseases and Epidemiology, Academician I.P. Pavlov First St. Petersburg State Medical University, Saint-Petersburg, Russian Federation.
Department of Medicine, Section of General Internal Medicine, Boston University School of Medicine/Boston Medical Center, Clinical Addiction Research and Education (CARE) Unit, Boston, MA, United States of America.
PLoS One. 2022 May 5;17(5):e0265504. doi: 10.1371/journal.pone.0265504. eCollection 2022.
We hypothesize that illicit opioid use increases bacterial translocation from the gut, which intensifies systemic inflammation.
To investigate the association between opioid use and plasma soluble CD14 [sCD14], interleukin-6 [IL-6] and D-dimer in people living with HIV (PLWH).
We analyzed data from the Russia ARCH study-an observational cohort of 351 ART-naive PLWH in St. Petersburg, Russia. Plasma levels of sCD14 (primary outcome), IL-6 and D-dimer (secondary outcomes) were evaluated at baseline, 12, and 24 months. Participants were categorized into three groups based on illicit opioid use: current, prior, and never opioid use. Linear mixed effects models were used to evaluate associations.
Compared to never opioid use, sCD14 levels were significantly higher for participants with current opioid use (AMD = 197.8 ng/ml [11.4, 384.2], p = 0.04). IL-6 levels were also higher for participants with current vs. never opioid use (ARM = 2.10 [1.56, 2.83], p <0.001). D-dimer levels were higher for current (ARM = 1.95 [1.43, 2.64], p <0.001) and prior (ARM = 1.57 [1.17, 2.09], p = 0.004) compared to never opioid use.
Among PLWH, current opioid use compared to never use is associated with increased monocyte activation and systemic inflammation.
我们假设非法阿片类药物的使用会增加肠道细菌易位，从而加剧全身炎症。
研究阿片类药物使用与人类免疫缺陷病毒（PLWH）感染者血浆可溶性 CD14 [sCD14]、白细胞介素-6 [IL-6]和 D-二聚体之间的关联。
我们分析了俄罗斯 ARCH 研究的数据-这是一个在俄罗斯圣彼得堡的 351 名未经抗逆转录病毒治疗（ART）的 PLWH 的观察性队列研究。在基线、12 个月和 24 个月时评估了血浆 sCD14（主要结果）、IL-6 和 D-二聚体（次要结果）的水平。根据非法阿片类药物的使用情况，参与者被分为三组：当前、以前和从未使用过阿片类药物。使用线性混合效应模型来评估关联。
与从未使用过阿片类药物相比，当前使用阿片类药物的参与者 sCD14 水平显著升高（AMD = 197.8ng/ml [11.4, 384.2]，p = 0.04）。与从未使用过阿片类药物相比，当前使用阿片类药物的参与者 IL-6 水平也更高（ARM = 2.10 [1.56, 2.83]，p <0.001）。与从未使用过阿片类药物相比，当前（ARM = 1.95 [1.43, 2.64]，p <0.001）和以前（ARM = 1.57 [1.17, 2.09]，p = 0.004）使用阿片类药物的参与者 D-二聚体水平更高。
在 PLWH 中，与从未使用过相比，当前使用阿片类药物与单核细胞激活和全身炎症增加有关。
