非法阿片类药物使用对 HIV 感染者单核细胞活化和全身炎症标志物的影响。
Impact of illicit opioid use on markers of monocyte activation and systemic inflammation in people living with HIV.
机构信息
Department of Infectious Diseases and Epidemiology, Academician I.P. Pavlov First St. Petersburg State Medical University, Saint-Petersburg, Russian Federation.
Department of Medicine, Section of General Internal Medicine, Boston University School of Medicine/Boston Medical Center, Clinical Addiction Research and Education (CARE) Unit, Boston, MA, United States of America.
出版信息
PLoS One. 2022 May 5;17(5):e0265504. doi: 10.1371/journal.pone.0265504. eCollection 2022.
INTRODUCTION
We hypothesize that illicit opioid use increases bacterial translocation from the gut, which intensifies systemic inflammation.
OBJECTIVE
To investigate the association between opioid use and plasma soluble CD14 [sCD14], interleukin-6 [IL-6] and D-dimer in people living with HIV (PLWH).
METHODS
We analyzed data from the Russia ARCH study-an observational cohort of 351 ART-naive PLWH in St. Petersburg, Russia. Plasma levels of sCD14 (primary outcome), IL-6 and D-dimer (secondary outcomes) were evaluated at baseline, 12, and 24 months. Participants were categorized into three groups based on illicit opioid use: current, prior, and never opioid use. Linear mixed effects models were used to evaluate associations.
RESULTS
Compared to never opioid use, sCD14 levels were significantly higher for participants with current opioid use (AMD = 197.8 ng/ml [11.4, 384.2], p = 0.04). IL-6 levels were also higher for participants with current vs. never opioid use (ARM = 2.10 [1.56, 2.83], p <0.001). D-dimer levels were higher for current (ARM = 1.95 [1.43, 2.64], p <0.001) and prior (ARM = 1.57 [1.17, 2.09], p = 0.004) compared to never opioid use.
CONCLUSIONS
Among PLWH, current opioid use compared to never use is associated with increased monocyte activation and systemic inflammation.
引言
我们假设非法阿片类药物的使用会增加肠道细菌易位，从而加剧全身炎症。
目的
研究阿片类药物使用与人类免疫缺陷病毒（PLWH）感染者血浆可溶性 CD14 [sCD14]、白细胞介素-6 [IL-6]和 D-二聚体之间的关联。
方法
我们分析了俄罗斯 ARCH 研究的数据-这是一个在俄罗斯圣彼得堡的 351 名未经抗逆转录病毒治疗（ART）的 PLWH 的观察性队列研究。在基线、12 个月和 24 个月时评估了血浆 sCD14（主要结果）、IL-6 和 D-二聚体（次要结果）的水平。根据非法阿片类药物的使用情况，参与者被分为三组：当前、以前和从未使用过阿片类药物。使用线性混合效应模型来评估关联。
结果
与从未使用过阿片类药物相比，当前使用阿片类药物的参与者 sCD14 水平显著升高（AMD = 197.8ng/ml [11.4, 384.2]，p = 0.04）。与从未使用过阿片类药物相比，当前使用阿片类药物的参与者 IL-6 水平也更高（ARM = 2.10 [1.56, 2.83]，p <0.001）。与从未使用过阿片类药物相比，当前（ARM = 1.95 [1.43, 2.64]，p <0.001）和以前（ARM = 1.57 [1.17, 2.09]，p = 0.004）使用阿片类药物的参与者 D-二聚体水平更高。
结论
在 PLWH 中，与从未使用过相比，当前使用阿片类药物与单核细胞激活和全身炎症增加有关。
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