Cao Ling, Wang Panpan, Chen Li, Wu Ying, Di Junwei
College of Chemistry, Chemical Engineering and Material Science, Soochow University Suzhou 215123 PR China
RSC Adv. 2019 May 16;9(27):15307-15313. doi: 10.1039/c9ra02088h. eCollection 2019 May 14.
This work reports the first construction of the ternary layers of ITO/PbS/SiO/AuNPs nanostructure for development of photoelectrochemical (PEC) glucose sensor. Herein, the thioglycolic acid-capped PbS quantum dots was employed as a PEC active probe, which is very sensitive to oxygen. The small gold nanoparticles (AuNPs) were act as nanozyme (mimic enzyme of glucose oxidase) to catalytically oxidize glucose in the presence of oxygen, meanwhile consumed oxygen and then resulted in the decrease of cathodic photocurrent. The insertion layer of SiO nanoparticles between PbS and AuNPs could reduce efficiently the base current due to its low electroconductivity, which improved the detection limit. The proposed PEC sensor exhibited high sensitivity and gold selectivity towards glucose. The linear response of glucose concentrations ranged from 1.0 μM to 1.0 mM with detection limit of 0.46 μM (S/N = 3). The results suggest the potential of design and development of numerous nanozyme-based PEC biosensors with the advantage of the simplicity, stability, and efficiency.
这项工作报道了首次构建用于开发光电化学（PEC）葡萄糖传感器的ITO/PbS/SiO/AuNPs纳米结构三元层。在此，巯基乙酸包覆的PbS量子点被用作PEC活性探针，其对氧气非常敏感。小尺寸金纳米颗粒（AuNPs）充当纳米酶（葡萄糖氧化酶的模拟酶），在有氧气存在的情况下催化氧化葡萄糖，同时消耗氧气，进而导致阴极光电流降低。PbS和AuNPs之间的SiO纳米颗粒插入层由于其低电导率可有效降低基电流，从而提高了检测限。所提出的PEC传感器对葡萄糖表现出高灵敏度和良好的选择性。葡萄糖浓度的线性响应范围为1.0 μM至1.0 mM，检测限为0.46 μM（S/N = 3）。结果表明设计和开发众多基于纳米酶的PEC生物传感器具有潜力，具有简单、稳定和高效的优点。
