Sawalha Hanadi, Moulton Simon E, Winkel Andreas, Stiesch Meike, Zaferanloo Bita
Department of Chemistry and Biotechnology, School of Science, Computing and Engineering Technologies, Swinburne University of Technology, Hawthorn, VIC 3122, Australia.
School of Engineering, Swinburne University of Technology, Melbourne, VIC 3122, Australia.
J Funct Biomater. 2025 Apr 3;16(4):129. doi: 10.3390/jfb16040129.
Metal nanoparticles (MNPs) produced through biosynthesis approaches have shown favourable physical, chemical, and antimicrobial characteristics. The significance of biological agents in the synthesis of MNPs has been acknowledged as a promising alternative to conventional approaches such as physical and chemical methods, which are confronted with certain challenges. To meet these challenges, the use of endophytic fungi as nano-factories for the synthesis of MNPs has become increasingly popular worldwide in recent times. This review provides an overview of the synthesis of MNPs using endophytic fungi, the mechanisms involved, and their important biomedical applications. A special focus on different biomedical applications of MNPs mediated endophytic fungi involved their antibacterial, antifungal, antiviral, and anticancer applications and their potential as drug delivery agents. Furthermore, this review highlights the significance of the use of endophytic fungi for the green synthesis of MNPs and discusses the benefits, challenges, and prospects in this field.
通过生物合成方法制备的金属纳米颗粒（MNPs）已显示出良好的物理、化学和抗菌特性。生物制剂在MNPs合成中的重要性已被公认为是传统方法（如物理和化学方法）的一种有前景的替代方法，而传统方法面临着某些挑战。为了应对这些挑战，近年来，将内生真菌用作合成MNPs的纳米工厂在全球范围内越来越普遍。本文综述了利用内生真菌合成MNPs的方法、相关机制及其重要的生物医学应用。特别关注了由内生真菌介导的MNPs的不同生物医学应用，包括它们的抗菌、抗真菌、抗病毒和抗癌应用以及作为药物递送剂的潜力。此外，本文强调了利用内生真菌进行MNPs绿色合成的重要性，并讨论了该领域的益处、挑战和前景。
