泰国患者对不同形式书面药物信息的药物安全知识与认知：一项比较研究。
Thai Patients' Drug Safety Knowledge and Perceptions Relating to Different Forms of Written Medicine Information: A Comparative Study.
作者信息
Wongtaweepkij Kamonphat, Krska Janet, Pongpunna Supawinee, Pongwecharak Juraporn, Jarernsiripornkul Narumol
机构信息
Division of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen, Thailand.
Medway School of Pharmacy, The Universities of Greenwich and Kent, Kent, UK.
出版信息
Patient Prefer Adherence. 2022 Apr 29;16:1141-1152. doi: 10.2147/PPA.S361447. eCollection 2022.
PURPOSE
The aim of the study was to evaluate the medication safety knowledge, quality of the written medicine information (WMI), and perceptions of taking the medicines in patients receiving package inserts (PIs) in comparison with patient information leaflets (PILs).
METHODS
A cross-sectional, comparative study was conducted from December 2020 to May 2021 at two university hospitals in Thailand. Outpatients who visited the pharmacy departments and were prescribed one of the three medicines: atorvastatin, celecoxib, or metformin were randomly selected by a permuted block randomization. The medication safety knowledge was measured using a set of validated and closed questions. The quality of the WMI was measured by the Consumer Information Rating Form (CIRF). Satisfaction with information and perceptions of the benefits and risks of medications were rated by the participants using a visual analog scale (0 to 10).
RESULTS
Of the 1150 invited patients, 750 completed the questionnaires (65.2%). A higher proportion of respondents with high level of medication safety knowledge was found in those reading the PILs than the PIs (44.5% and 20.8%, respectively). The type of leaflet received was a significant predictor of the high knowledge level (p < 0.001). The mean CIRF scores were significantly higher among those reading the PILs than the PIs (p < 0.001). Patients reading the PILs were also more satisfied with the information and had more positive perceptions of the benefits from taking medicines and intention to adhere than those reading the PIs. Patients' perceptions of risks after reading both leaflets were moderate (median score = 5.0), with the PIL group having slightly more concern about risks than the PI group.
CONCLUSION
The PILs showed superior effectiveness to the PIs in enhancing knowledge about medication safety, providing greater satisfaction with the information, and positive perceptions of benefit and intention to comply with the medications. PILs should be provided more frequently to patients receiving medicines than PIs.
目的
本研究旨在评估接受药品说明书（PIs）的患者与接受患者信息单页（PILs）的患者在用药安全知识、书面药品信息（WMI）质量以及用药认知方面的差异。
方法
2020年12月至2021年5月在泰国的两家大学医院进行了一项横断面比较研究。到药房就诊且被处方阿托伐他汀、塞来昔布或二甲双胍这三种药物之一的门诊患者通过置换区组随机化进行随机选择。用药安全知识通过一组经过验证的封闭式问题进行测量。WMI的质量通过消费者信息评级表（CIRF）进行测量。参与者使用视觉模拟量表（0至10）对信息满意度以及对药物益处和风险的认知进行评分。
结果
在1150名受邀患者中，750名完成了问卷调查（65.2%）。阅读PILs的患者中具有高水平用药安全知识的受访者比例高于阅读PIs的患者（分别为44.5%和20.8%）。所收到的说明书类型是高知识水平的显著预测因素（p < 0.001）。阅读PILs的患者的CIRF平均得分显著高于阅读PIs的患者（p < 0.001）。阅读PILs的患者对信息也更满意，并且对用药益处的认知更积极，用药依从性意愿也高于阅读PIs的患者。阅读两种说明书后患者对风险的认知为中等（中位数得分 = 5.0），PIL组比PI组对风险的担忧略多。
结论
在增强用药安全知识、提高信息满意度以及对益处和用药依从性意愿的积极认知方面，PILs显示出比PIs更优的效果。应比PIs更频繁地向接受药物治疗的患者提供PILs。
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