Pashchenko A V, Liedienov N A, Fesych I V, Li Quanjun, Pitsyuga V G, Turchenko V A, Pogrebnyak V G, Liu Bingbing, Levchenko G G
State Key Laboratory of Superhard Materials, International Center of Future Science, Jilin University 130012 Changchun China
Donetsk Institute for Physics and Engineering named after O.O. Galkin, NAS of Ukraine 03028 Kyiv Ukraine
RSC Adv. 2020 Aug 20;10(51):30907-30916. doi: 10.1039/d0ra06779b. eCollection 2020 Aug 17.
For many medical applications related to diagnosis and treatment of cancer disease, hyperthermia plays an increasingly important role as a local heating method, where precise control of temperature and parameters of the working material is strongly required. Obtaining a smart material with "self-controlled" heating in a desirable temperature range is a relevant task. For this purpose, the nanopowder of manganite perovskite with super-stoichiometric manganese has been synthesized, which consists of soft spherical-like ferromagnetic nanoparticles with an average size of 65 nm and with a narrow temperature range of the magnetic phase transition at 42 °C. Based on the analysis of experimental magnetic data, a specific loss power has been calculated for both quasi-stable and relaxation hysteresis regions. It has been shown that the local heating of the cell structures to 42 °C may occur for a short time (∼1.5 min.) Upon reaching 42 °C, the heating is stopped due to transition of the nanopowder to the paramagnetic state. The obtained results demonstrate the possibility of using synthesized nanopowder as a smart magnetic nanomaterial for local hyperthermia with automatic heating stabilization in the safe range of hyperthermia without the risk of mechanical damage to cell structures.
对于许多与癌症疾病诊断和治疗相关的医学应用而言，热疗作为一种局部加热方法发挥着越来越重要的作用，在这种情况下，对温度和工作材料参数的精确控制是非常必要的。获得一种能在理想温度范围内“自我控制”加热的智能材料是一项相关任务。为此，合成了具有超化学计量锰的锰酸盐钙钛矿纳米粉末，它由平均尺寸为65纳米的软球形铁磁纳米颗粒组成，且磁相变温度范围较窄，为42℃。基于对实验磁数据的分析，计算了准稳定和弛豫磁滞区域的比损耗功率。结果表明，细胞结构在短时间内（约1.5分钟）可能会被局部加热到42℃。当达到42℃时，由于纳米粉末转变为顺磁状态，加热停止。所得结果证明了使用合成纳米粉末作为智能磁性纳米材料进行局部热疗的可能性，该材料可在热疗安全范围内实现自动加热稳定，且不存在对细胞结构造成机械损伤的风险。
