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洛尼马克兰内酯A - C，三种具有新颖骨架的环烯醚萜类化合物，源自于…… （原文此处不完整）

Lonimacranaldes A-C, three iridoids with novel skeletons from .

作者信息

Mei Yu-Dan, Li Hai-Bo, Pang Qian-Qian, Li Ting, Pan Da-Bo, Dai Yi, Qin Da-Peng, Meng He, Yao Xin-Sheng, Yu Yang

机构信息

Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University Guangzhou 510632 P. R. China

Xiangxue Academician Workstation, Xiangxue Pharmaceutical Co. Ltd. Guangzhou 510663 P. R. China.

出版信息

RSC Adv. 2019 Jul 16;9(38):22011-22016. doi: 10.1039/c9ra04029c. eCollection 2019 Jul 11.

DOI:10.1039/c9ra04029c
PMID:35518883
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9066900/
Abstract

Lonimacranaldes A and B (1 and 2), along with one biogenetically related intermediate, lonimacranalde C (3), were isolated from the flower buds of . Characterized by an iridoid structure and an additional C-6 unit with an aldehyde group, compounds 1 and 2 are the first examples of hybrid iridoids possessing an unexpected 6/5/6 fused tricyclic ring system, while compound 3 serves as an important precursor for their generation. The structures of lonimacranaldes A-C (1-3) were revealed by extensive spectroscopic and X-ray diffraction analyses. A plausible biogenetic pathway for them was proposed. Compound 3 showed anti-inflammatory activities by inhibiting the production of IL-6 on LPS-induced RAW 264.7 cells with an IC value of 6.33 μM.

摘要

从[植物名称]的花芽中分离出了洛尼马克兰醛A和B（1和2），以及一种生源相关中间体洛尼马克兰醛C（3）。化合物1和2具有环烯醚萜结构以及一个带有醛基的额外C-6单元，是具有意外的6/5/6稠合三环体系的杂交环烯醚萜的首个实例，而化合物3是它们生成的重要前体。通过广泛的光谱分析和X射线衍射分析揭示了洛尼马克兰醛A - C（1 - 3）的结构。并提出了一个合理的生源途径。化合物3通过抑制脂多糖诱导的RAW 264.7细胞中IL-6的产生而显示出抗炎活性，IC值为6.33 μM。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2af1/9066900/e9833f3feda9/c9ra04029c-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2af1/9066900/70a7474bf326/c9ra04029c-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2af1/9066900/2c54eee5f321/c9ra04029c-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2af1/9066900/e04749d2fc3d/c9ra04029c-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2af1/9066900/94e0a348e95c/c9ra04029c-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2af1/9066900/afdfaee9600b/c9ra04029c-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2af1/9066900/9586c1341b4e/c9ra04029c-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2af1/9066900/e9833f3feda9/c9ra04029c-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2af1/9066900/70a7474bf326/c9ra04029c-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2af1/9066900/2c54eee5f321/c9ra04029c-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2af1/9066900/e04749d2fc3d/c9ra04029c-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2af1/9066900/94e0a348e95c/c9ra04029c-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2af1/9066900/afdfaee9600b/c9ra04029c-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2af1/9066900/9586c1341b4e/c9ra04029c-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2af1/9066900/e9833f3feda9/c9ra04029c-f6.jpg

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