白花油麻藤中的生物活性 5/5/5/6 四环系统环烯醚萜

Bioactive 5/5/5/6 Four-Ring System Iridoids from Plumeria alba L.

机构信息

Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education Hainan Normal University, Haikou, Hainan, 571158, China.

Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, Hainan, 571158, China.

出版信息

Chem Biodivers. 2024 Apr;21(4):e202400188. doi: 10.1002/cbdv.202400188. Epub 2024 Mar 14.

DOI:10.1002/cbdv.202400188

PMID:38372184

Abstract

Two rare 5/5/5/6 four-ring system iridoids, allamancins A and B (1 and 2) together with one known biogenetically related iridoid derivative, 3-O-methyallamancin (3) were isolated from the flowers of Plumeria alba L. The structures of these iridoid derivatives were determined by comprehensive spectroscopic analyses. The absolute configuration of 1 was confirmed by X-ray crystallographic analysis. The inhibitory activities of compounds 1-3 against nitric oxide (NO) production induced and three cancer cell lines were evaluated in vitro. Compounds 1 and 3 showed inhibitory activities on NO production with IC values of 18.3±0.12 and 22.1±0.14 μM, respectively. Compounds 1-3 showed moderate inhibitory activities against cancer cell lines of A549, Hela and MCF-7.

摘要

两种罕见的 5/5/5/6 四环系统裂环环烯醚萜，即阿马林辛 A 和 B（1 和 2），以及一种已知的生物相关裂环环烯醚萜衍生物 3-O-甲基阿马林辛（3），从白花夹竹桃的花朵中分离得到。通过综合光谱分析确定了这些裂环环烯醚萜衍生物的结构。通过 X 射线晶体学分析确定了 1 的绝对构型。在体外评估了化合物 1-3 对一氧化氮（NO）产生的抑制活性和三种癌细胞系。化合物 1 和 3 对 NO 产生具有抑制活性，IC 值分别为 18.3±0.12 和 22.1±0.14 μM。化合物 1-3 对 A549、Hela 和 MCF-7 癌细胞系表现出中等抑制活性。