Chen Hao, Li Biyun, Feng Bei, Wang Hao, Yuan Huihua, Xu Zhiwei
Department of Cardiothoracic Surgery, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University Shanghai 200127 China
School of Life Sciences, Nantong University Nantong Jiangsu 226019 China
RSC Adv. 2019 Jun 21;9(34):19523-19530. doi: 10.1039/c9ra02628b. eCollection 2019 Jun 19.
Citric modified chitosan (CC) hydrogel containing antibacterial drugs is developed by the freezing and thawing treatment method. The SEM image of the CC hydrogel revealed a porous structure. The rheological properties, porosity, swelling rate, water uptake, tensile properties and degradation were found to be tunable CC concentration. To enhance antibacterial properties, tetracycline hydrochloride (TH) representing the drug model, was integrated into the CC hydrogel. The cumulative release of drug was also tunable CC concentration. The drug loaded CC hydrogel showed enhanced antimicrobial activity against and . In animal tests, it was found the TH loaded CC hydrogel accelerated the healing of the wounds created on rats. These results suggest that the drug loaded CC hydrogel has a promising future in wound healing as a wound dressing.
通过冻融处理法制备了含抗菌药物的柠檬酸修饰壳聚糖（CC）水凝胶。CC水凝胶的扫描电子显微镜图像显示出多孔结构。发现流变性能、孔隙率、溶胀率、吸水率、拉伸性能和降解性能可通过CC浓度进行调节。为增强抗菌性能，将代表药物模型的盐酸四环素（TH）融入CC水凝胶中。药物的累积释放也可通过CC浓度进行调节。载药CC水凝胶对……和……显示出增强的抗菌活性。在动物试验中，发现载有TH的CC水凝胶加速了大鼠伤口的愈合。这些结果表明，载药CC水凝胶作为伤口敷料在伤口愈合方面具有广阔的前景。
