Bochicchio Sabrina, Lamberti Gaetano, Barba Anna Angela
Eng4Life Srl, Spin-Off Accademico, Via Fiorentino, 32, 83100 Avellino, Italy.
Dipartimento di Ingegneria Industriale, Università Degli Studi di Salerno, Via Giovanni Paolo II, 132, 84084 Fisciano, Italy.
Pharmaceutics. 2021 Feb 2;13(2):198. doi: 10.3390/pharmaceutics13020198.
Some issues in pharmaceutical therapies such as instability, poor membrane permeability, and bioavailability of drugs can be solved by the design of suitable delivery systems based on the combination of two pillar classes of ingredients: polymers and lipids. At the same time, modern technologies are required to overcome production limitations (low productivity, high energy consumption, expensive setup, long process times) to pass at the industrial level. In this paper, a summary of applications of polymeric and lipid materials combined as nanostructures (hybrid nanocarriers) is reported. Then, recent techniques adopted in the production of hybrid nanoparticles are discussed, highlighting limitations still present that hold back the industrial implementation.
药物治疗中的一些问题，如药物的不稳定性、较差的膜通透性和生物利用度，可以通过基于聚合物和脂质这两类主要成分组合设计合适的给药系统来解决。同时，需要现代技术来克服生产限制（低生产率、高能耗、昂贵的设备、较长的加工时间），以便达到工业生产水平。本文报道了聚合物和脂质材料组合形成纳米结构（混合纳米载体）的应用总结。然后，讨论了混合纳米颗粒生产中采用的最新技术，突出了仍然存在的阻碍工业应用的局限性。
