通过铜催化的2-炔基苯酚和对甲苯磺酰苯胺的分子内环化反应简便合成2-取代苯并呋喃和吲哚。
Facile synthesis of 2-substituted benzo[]furans and indoles by copper-catalyzed intramolecular cyclization of 2-alkynyl phenols and tosylanilines.
作者信息
Rong Zhouting, Gao Kexin, Zhou Lei, Lin Jianyuan, Qian Guoying
机构信息
College of Biological and Environmental Sciences, Zhejiang Wanli University Ningbo 315100 People's Republic of China
出版信息
RSC Adv. 2019 Jun 7;9(31):17975-17978. doi: 10.1039/c9ra01260e. eCollection 2019 Jun 4.
Abstract
A catalytic amount of CuCl and CsCO was employed to synthesize a variety of 2-substituted benzo[]furans and indoles by an intramolecular cyclization of 2-alkynyl phenols and tosylanilines. This protocol features mild conditions, high yields and broad substrate scope, which makes it a practical method for the synthesis of 2-substituted benzo[]furans and indoles.
摘要
使用催化量的氯化铜和碳酸铯，通过2-炔基苯酚和对甲苯磺酰苯胺的分子内环化反应合成了多种2-取代苯并呋喃和吲哚。该方法具有条件温和、产率高和底物范围广的特点，使其成为合成2-取代苯并呋喃和吲哚的实用方法。
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