Navarro Lucila, Minari Roque J, Vaillard Santiago E
Instituto de Desarrollo Tecnológico para la Industria Química (INTEC), CCT-Santa Fe CONICET-UNL. Colectora Ruta Nacional 168, Km 1, Predio "Dr. Alberto Cassano", Paraje "EL Pozo" Santa Fe 3000 Argentina
RSC Adv. 2019 Jan 2;9(1):482-490. doi: 10.1039/c8ra09336a. eCollection 2018 Dec 19.
Elastomeric poly-ester materials have extraordinary potential for soft tissue engineering applications. In connection, in the last 10 years, cross-linkable oligo-(polyethylene glycol fumarate)s emerged as promising materials for obtaining hydrogels for bone tissue engineering applications. In this work we prepared a new family of photo-curable poly-(ethylene glycol)-fumarate elastomers with controlled structural composition. These novel elastomers were obtained by photo-curing of fumarate pre-polymers based on diethylene glycol and oligo-ethylene glycols (PEGs 200 and 400), under extremely mild experimental conditions using a low power UV source. The synthesis of fumarate pre-polymers, which were obtained by thermal poly-condensation, and the photo-curing process, were both here discussed on the basis of their structural differences and proposed operating mechanisms. Finally, the photo-radical cross-linking reactions were performed in the presence of anti-cancer drugs (doxorubicin and paclitaxel), in order to evaluate the potential application of the elastomers as new eluting systems. Thus, different release profiles were obtained for hydrophilic (doxorubicin) and hydrophobic (paclitaxel) anticancer drugs, and these differences are discussed on the basis of the structure of the elastomers.
弹性聚酯材料在软组织工程应用中具有巨大潜力。与此相关的是，在过去十年中，可交联的聚（乙二醇富马酸酯）低聚物成为用于骨组织工程应用中制备水凝胶的有前景的材料。在这项工作中，我们制备了一系列具有可控结构组成的光固化聚（乙二醇）-富马酸酯弹性体。这些新型弹性体是通过基于二甘醇和低聚乙二醇（PEG 200和400）的富马酸酯预聚物在极低功率紫外光源的极其温和的实验条件下进行光固化而获得的。本文基于其结构差异和提出的作用机制讨论了通过热缩聚获得的富马酸酯预聚物的合成以及光固化过程。最后，在抗癌药物（阿霉素和紫杉醇）存在的情况下进行光自由基交联反应，以评估弹性体作为新型洗脱系统的潜在应用。因此，对于亲水性（阿霉素）和疏水性（紫杉醇）抗癌药物获得了不同的释放曲线，并基于弹性体的结构对这些差异进行了讨论。
