肾细胞癌患者血清中抗Tamm-Horsfall蛋白抗体

Serum antibody against Tamm-Horsfall protein in patients with renal cell carcinoma.

作者信息

Fowler J E, Frierson H F, Mills S E, Mariano M

出版信息

Cancer. 1987 Jun 1;59(11):1923-6. doi: 10.1002/1097-0142(19870601)59:11<1923::aid-cncr2820591114>3.0.co;2-8.

DOI:10.1002/1097-0142(19870601)59:11<1923::aid-cncr2820591114>3.0.co;2-8

Abstract

We assayed sera from 24 patients with metastatic renal cell carcinoma for class specific antibody against urinary Tamm-Horsfall protein (THP) using indirect solid-phase radioimmunoassay techniques. Overall, 16 patients had elevated antibody levels (greater than 2 SD above the mean levels of control subjects). IgG against THP was elevated in eight of the patients, IgA in 12, and IgM in five. However, THP was not identifiable by immunohistochemical techniques in the sections of 15 of 24 tumors available for study. Nine of the 15 tumors were from patients with elevated antibody levels. Serum antibody against THP in patients with renal cell carcinoma appears to result from antigenic stimulation by THP derived from the urine rather than from the neoplasm.

摘要

我们采用间接固相放射免疫测定技术，检测了24例转移性肾细胞癌患者血清中针对尿Tamm-Horsfall蛋白（THP）的类别特异性抗体。总体而言，16例患者抗体水平升高（高于对照受试者平均水平2个标准差以上）。8例患者针对THP的IgG升高，12例IgA升高，5例IgM升高。然而，在可供研究的24个肿瘤切片中，15个肿瘤通过免疫组织化学技术无法鉴定出THP。15个肿瘤中有9个来自抗体水平升高的患者。肾细胞癌患者血清中针对THP的抗体似乎是由尿液来源的THP抗原刺激产生的，而非肿瘤来源。