Department of Public Health and Clinical Medicine, Skellefteå Research Unit, Umeå University, Umeå, Sweden.
Department of Public Health and Clinical Medicine, Skellefteå Research Unit, Umeå University, Umeå, Sweden.
Thromb Res. 2022 Jun;214:82-86. doi: 10.1016/j.thromres.2022.04.014. Epub 2022 Apr 26.
Studies have indicated that men have a higher overall risk of VTE than women. In previous studies, we have noted that risk factors for VTE, such as alcohol consumption and physical activity, can differ between sexes. The aim of the present study was to estimate the incidence of first-ever VTE and the association of traditional cardiovascular risk factors with VTE risk in men and women separately.
Inhabitants of Västerbotten County in northern Sweden, who had participated in a health examination between 1985 and 2014 were included. The mean age at inclusion was 46.3 years (range 26-65 years). All first-ever VTE events experienced by the participants from the health examination to September 5, 2014 were identified and validated.
A total of 1110 men and 944 women had an objectively verified first-ever VTE event. The incidence of VTE was 1.54 (95% CI 1.45-1.63) per 1000 years of follow-up for men and 1.22 (95% CI 1.14-1.30) for women. Higher age, weight and body mass index were associated with increased risk of VTE in both sexes. Men with hypertension had a lower risk of VTE, HR 0.75 (95% CI 0.65-0.87) and men with more than secondary school education had a higher risk of VTE. Taller women had an increased risk of VTE.
In the studied age group, we found that men had a higher incidence of first-ever VTE than women. Notably, we also found that hypertension was associated with lower risk of VTE in men but not in women.
研究表明，男性发生静脉血栓栓塞症（VTE）的总体风险高于女性。在之前的研究中，我们注意到 VTE 的风险因素，如饮酒和身体活动，在男女之间可能存在差异。本研究旨在分别估计男性和女性首次 VTE 的发生率，以及传统心血管风险因素与 VTE 风险的相关性。
纳入了瑞典北部韦斯特博滕县的居民，他们参加了 1985 年至 2014 年期间的健康检查。纳入时的平均年龄为 46.3 岁（26-65 岁）。从健康检查到 2014 年 9 月 5 日，确定并验证了参与者中所有首次发生的 VTE 事件。
共有 1110 名男性和 944 名女性发生了客观证实的首次 VTE 事件。男性 VTE 的发生率为每 1000 年随访 1.54（95%CI 1.45-1.63），女性为 1.22（95%CI 1.14-1.30）。在两性中，年龄较大、体重和身体质量指数较高与 VTE 风险增加相关。高血压男性的 VTE 风险较低，HR 0.75（95%CI 0.65-0.87），接受过高中以上教育的男性 VTE 风险较高。较高的女性身高与 VTE 风险增加相关。
在所研究的年龄组中，我们发现男性首次 VTE 的发生率高于女性。值得注意的是，我们还发现高血压与男性而非女性的 VTE 风险较低有关。
